Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial

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Data
2019
Autores
Santos Filho, Paulo Samuel
Santos, Marisa
Colafranceschi, Alexandre Siciliano
Pragana, Andrea Nunes de Souza
Correia, Marcelo Goulart
Simões, Heloisa Helena
Rocha, Fernando Alves
Soggia, Maria Eduarda de Vasconcelos
Santos, Ana Paula Malta Samuel
Coutinho, Annie de Azeredo
Journal Title
Journal ISSN
Volume Title
Publisher
Brazilian journal of Cardiovascular Surgery
Resumo
Objective: To evaluate the efficacy of triclosan-coated suture for the reduction of infection in saphenectomy wounds of patients undergoing coronary artery bypass graft (CABG) surgery.Methods: A total of 508 patients who underwent saphenectomy in CABG surgery were included in a prospective, randomized, double-blind trial from February/2011 to June/2014. Patients were randomized into the triclosan-coated suture group (n= 251) and the conventional non-antibiotic suture group (n=257). Demographic (gender and age), clinical (body mass index, diabetes, and use of analgesics), and intraoperative (cardiopulmonary bypass and cross-clamp times) variables and those related to the saphenectomy wound (pain, dehiscence, erythema, infection, necrosis, and hyperthermia) were measured and analyzed.Results: Of the 508 patients who underwent saphenectomy, 69.9% were males and 40.2% were diabetic. Thirty-three (6.5%) patients presented infection: 13 (5.3%) with triclosan and 20 (7.9%) with conventional suture (P=0.281). Among diabetic patients (n=204), triclosan suture was used in 45.1% with four cases of infection; conventional suture was used in 54.9% of them, with 11 cases of infection. Most patients (94.3%) underwent on-pump CABG. Wound pain was observed in 9.9% of patients with triclosan-coated suture and in 17.9% with conventional suture (P=0.011). Wound hyperthermia was found in 1.6% of patients with triclosan-coated suture and in 5.4% of those with conventional suture (P=0.028).Conclusion: Triclosan-coated suture shows lower infection rate in saphenectomy of patients undergoing CABG, although the differences were not statistically significant. Pain and wound hyperthermia were less frequent in patients with triclosan-coated sutures compared with conventional sutures.
Description
Palavras-chave
Wound Infection, Sutures, Triclosan, Coronary Artery Bypass Graft, Cardiopulmonary Bypass, Erythema, Body Mass Index, Analgesics, Pain
Citação
Santos PS Filho, Santos M, Colafranceschi AS, Pragana ANS, Correia MG, Simões HH, Rocha FA, Soggia MEV, Santos APMS, Coutinho AA, Figueira MS, Tura BR. Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial. Braz J Cardiovasc Surg. 2019 Dec 1;34(5):588-595.