Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial

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dc.contributor.authorSantos Filho, Paulo Samuel
dc.contributor.authorSantos, Marisa
dc.contributor.authorColafranceschi, Alexandre Siciliano
dc.contributor.authorPragana, Andrea Nunes de Souza
dc.contributor.authorCorreia, Marcelo Goulart
dc.contributor.authorSimões, Heloisa Helena
dc.contributor.authorRocha, Fernando Alves
dc.contributor.authorSoggia, Maria Eduarda de Vasconcelos
dc.contributor.authorSantos, Ana Paula Malta Samuel
dc.contributor.authorCoutinho, Annie de Azeredo
dc.contributor.authorFigueira, Matheus Swarovsky
dc.contributor.authorTura, Bernardo Rangel
dc.date.accessioned2022-08-04T17:55:00Z
dc.date.available2022-08-04T17:55:00Z
dc.date.issued2019
dc.description.abstractObjective: To evaluate the efficacy of triclosan-coated suture for the reduction of infection in saphenectomy wounds of patients undergoing coronary artery bypass graft (CABG) surgery.Methods: A total of 508 patients who underwent saphenectomy in CABG surgery were included in a prospective, randomized, double-blind trial from February/2011 to June/2014. Patients were randomized into the triclosan-coated suture group (n= 251) and the conventional non-antibiotic suture group (n=257). Demographic (gender and age), clinical (body mass index, diabetes, and use of analgesics), and intraoperative (cardiopulmonary bypass and cross-clamp times) variables and those related to the saphenectomy wound (pain, dehiscence, erythema, infection, necrosis, and hyperthermia) were measured and analyzed.Results: Of the 508 patients who underwent saphenectomy, 69.9% were males and 40.2% were diabetic. Thirty-three (6.5%) patients presented infection: 13 (5.3%) with triclosan and 20 (7.9%) with conventional suture (P=0.281). Among diabetic patients (n=204), triclosan suture was used in 45.1% with four cases of infection; conventional suture was used in 54.9% of them, with 11 cases of infection. Most patients (94.3%) underwent on-pump CABG. Wound pain was observed in 9.9% of patients with triclosan-coated suture and in 17.9% with conventional suture (P=0.011). Wound hyperthermia was found in 1.6% of patients with triclosan-coated suture and in 5.4% of those with conventional suture (P=0.028).Conclusion: Triclosan-coated suture shows lower infection rate in saphenectomy of patients undergoing CABG, although the differences were not statistically significant. Pain and wound hyperthermia were less frequent in patients with triclosan-coated sutures compared with conventional sutures.en
dc.identifier.citationSantos PS Filho, Santos M, Colafranceschi AS, Pragana ANS, Correia MG, Simões HH, Rocha FA, Soggia MEV, Santos APMS, Coutinho AA, Figueira MS, Tura BR. Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial. Braz J Cardiovasc Surg. 2019 Dec 1;34(5):588-595.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/55
dc.language.isoen
dc.publisherBrazilian journal of Cardiovascular Surgery
dc.subjectWound Infectionen
dc.subjectSuturesen
dc.subjectTriclosanen
dc.subjectCoronary Artery Bypass Graften
dc.subjectCardiopulmonary Bypassen
dc.subjectErythemaen
dc.subjectBody Mass Indexen
dc.subjectAnalgesicsen
dc.subjectPainen
dc.subject.meshTriclosan / therapeutic useen
dc.subject.meshTreatment Outcomeen
dc.subject.meshTime Factorsen
dc.subject.meshSuture Techniquesen
dc.subject.meshSurgical Wound Infection / prevention & controlen
dc.subject.meshStatistics, Nonparametricen
dc.subject.meshSaphenous Vein / surgeryen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshProspective Studiesen
dc.subject.meshPolyglactin 910 / therapeutic useen
dc.subject.meshPain, Postoperative / prevention & controlen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshDouble-Blind Methoden
dc.subject.meshDiabetes Complicationsen
dc.subject.meshCoronary Artery Bypass / methodsen
dc.subject.meshCoronary Artery Bypass / adverse effectsen
dc.subject.meshBody Mass Indexen
dc.subject.meshAnti-Infective Agents, Local / therapeutic useen
dc.subject.meshAged, 80 and overen
dc.subject.meshAgeden
dc.subject.meshAdulten
dc.titleEffect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trialen
dc.typeArticle
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