Is myocardial performance index an independent echocardiographic marker of death in children with idiopathic dilated cardiomyopathy?

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dc.contributor.authorAzevedo, Vitor Manuel P
dc.contributor.authorAlbanesi Filho, Francisco M
dc.contributor.authorSantos, Marco Aurélio
dc.contributor.authorCastier, Márcia B
dc.contributor.authorTura, Bernardo R
dc.contributor.authorAmino, José Geraldo
dc.contributor.authorCunha, Maria Ourinda Mesquita da
dc.date.accessioned2024-02-01T12:58:52Z
dc.date.available2024-02-01T12:58:52Z
dc.date.issued2008
dc.description.abstractBackground: Myocardial performance index (MPI) was reported as a parameter of ventricular systolic and diastolic function, as well as a useful tool to predict the outcome in patients with ventricular dysfunction. Hypothesis: To compare MPI with classical echocardiographic parameters as an independent marker of death in children with idiopathic dilated cardiomyopathy (IDCM). Methods: Fifty-five children (13 deaths) underwent 104 echocardiograms from January 1996 to May 2005. Right ventricle (RV) MPI and left ventricle (LV) MPI, and 9 classical echocardiographic parameters (left atrium [LA]/body surface area [BSA], distance between mitral E point and ventricular septum, LV mass/body surface area, RV shortening fraction, LV end-systolic and end-diastolic dimensions/body surface area, LV ejection fraction, fiber circumferential shortening velocity, and mitral deceleration time) were compared. Statistical analysis was performed by chi-square, Pearson's correlation and Student t-test, Kaplan-Meier method, Cox's method, and receiver operating curve (ROC). Statistical significance was considered with alpha<0.05 and p=0.80]. Results: Univariate analysis showed that all studied parameters were markers of death. There was a high correlation between RVMPI and LVMPI (r=0.847]-p=0.0001]); therefore, to avoid bias, RVMPI was discharged from multivariate analysis. In the deceased group, moderate/severe mitral regurgitation was frequent (76.9%; confidence interval [CI[ 95%=46.2%- 94.9%) and it was considered in multivariate analysis. In Cox's multivariate analysis, LVMPI was the only independent marker of death (p=0.0213]). The ideal cut-off was 0.63 with 92.3% sensitivity, 66.7% specificity, and fitted ROC area=0.918]. Conclusions: In children with IDCM, LVMPI is an independent marker of death.
dc.identifier.citationAzevedo VM, Albanesi Filho FM, Santos MA, Castier MB, Tura BR, Amino JG, Da Cunha MO. Is myocardial performance index an independent echocardiographic marker of death in children with idiopathic dilated cardiomyopathy? Clin Cardiol. 2008 Sep;31(9):424-30. doi: 10.1002/clc.20264.
dc.identifier.otherDOI: 10.1002/clc.20264
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/392
dc.language.isoen
dc.publisherClinical Cardiology
dc.subject.meshVentricular Functionen
dc.subject.meshSurvival Rateen
dc.subject.meshROC Curveen
dc.subject.meshMyocardial Contractionen
dc.subject.meshModels, Statisticalen
dc.subject.meshInfanten
dc.subject.meshHumansen
dc.subject.meshEchocardiographyen
dc.subject.meshChild, Preschoolen
dc.subject.meshChilden
dc.subject.meshCardiomyopathy, Dilated / physiopathologyen
dc.subject.meshCardiomyopathy, Dilated / mortalityen
dc.subject.meshCardiomyopathy, Dilated / diagnostic imagingen
dc.subject.meshAdolescenten
dc.titleIs myocardial performance index an independent echocardiographic marker of death in children with idiopathic dilated cardiomyopathy?
dc.typeArticle
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