Is myocardial performance index an independent echocardiographic marker of death in children with idiopathic dilated cardiomyopathy?
Is myocardial performance index an independent echocardiographic marker of death in children with idiopathic dilated cardiomyopathy?
Data
2008
Autores
Azevedo, Vitor Manuel P
Albanesi Filho, Francisco M
Santos, Marco Aurélio
Castier, Márcia B
Tura, Bernardo R
Amino, José Geraldo
Cunha, Maria Ourinda Mesquita da
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Publisher
Clinical Cardiology
Resumo
Background: Myocardial performance index (MPI) was reported as a parameter of ventricular systolic and diastolic function, as well as a useful tool to predict the outcome in patients with ventricular dysfunction.
Hypothesis: To compare MPI with classical echocardiographic parameters as an independent marker of death in children with idiopathic dilated cardiomyopathy (IDCM).
Methods: Fifty-five children (13 deaths) underwent 104 echocardiograms from January 1996 to May 2005. Right ventricle (RV) MPI and left ventricle (LV) MPI, and 9 classical echocardiographic parameters (left atrium [LA]/body surface area [BSA], distance between mitral E point and ventricular septum, LV mass/body surface area, RV shortening fraction, LV end-systolic and end-diastolic dimensions/body surface area, LV ejection fraction, fiber circumferential shortening velocity, and mitral deceleration time) were compared. Statistical analysis was performed by chi-square, Pearson's correlation and Student t-test, Kaplan-Meier method, Cox's method, and receiver operating curve (ROC). Statistical significance was considered with alpha<0.05 and p=0.80].
Results: Univariate analysis showed that all studied parameters were markers of death. There was a high correlation between RVMPI and LVMPI (r=0.847]-p=0.0001]); therefore, to avoid bias, RVMPI was discharged from multivariate analysis. In the deceased group, moderate/severe mitral regurgitation was frequent (76.9%; confidence interval [CI[ 95%=46.2%- 94.9%) and it was considered in multivariate analysis. In Cox's multivariate analysis, LVMPI was the only independent marker of death (p=0.0213]). The ideal cut-off was 0.63 with 92.3% sensitivity, 66.7% specificity, and fitted ROC area=0.918].
Conclusions: In children with IDCM, LVMPI is an independent marker of death.
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Azevedo VM, Albanesi Filho FM, Santos MA, Castier MB, Tura BR, Amino JG, Da Cunha MO. Is myocardial performance index an independent echocardiographic marker of death in children with idiopathic dilated cardiomyopathy? Clin Cardiol. 2008 Sep;31(9):424-30. doi: 10.1002/clc.20264.