Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery

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dc.contributor.authorMendonça-Filho, Hugo Tannus Furtado de
dc.contributor.authorGomes, Gleice Silva
dc.contributor.authorNogueira, Pedro Miguel Mattos
dc.contributor.authorFernandes, Marco Aurelio de Oliveira
dc.contributor.authorTura, Bernardo Rangel
dc.contributor.authorSantos, Marisa
dc.contributor.authorCastro-Faria-Neto, Hugo Caire
dc.date.accessioned2024-02-02T11:47:53Z
dc.date.available2024-02-02T11:47:53Z
dc.date.issued2005
dc.description.abstractThis prospective consecutive observational study describes the blood levels of macrophage migration inhibitory factor (MIF), other cytokines, and markers of acute-phase response in 49 consecutive patients who developed the clinical syndrome of sepsis after cardiac surgery. Before starting antimicrobial treatment, all patients underwent microbiologic screening, and blood samples were collected. These samples subsequently were assayed for MIF, macrophage chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and -10, procalcitonin (PCT), and C-reactive protein (CRP). Patients with positive cultures (n = 25) had a higher mortality (P = 0.046) and higher levels of MIF (P < 0.001) than those with negative cultures (n = 24). We could not detect significant difference between the groups concerning the levels of CRP, PCT, IL6, IL10, MCP-1, or TNF-alpha. MIF levels showed an area under receiver operator curve of 0.823 for the prediction of culture-proven bacterial infection, with the best cut-off value at 988.5 pg/mL. In conclusion, circulating levels of MIF could be indicated as a valuable marker of microbiologically documented sepsis in patients after cardiac surgery, which suggests that MIF may be prospectively explored as a useful diagnostic tool in this setting.
dc.identifier.citationde Mendonça-Filho HT, Gomes GS, Nogueira PM, Fernandes MA, Tura BR, Santos M, Castro-Faria-Neto HC. Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery. Shock. 2005 Oct;24(4):313-7. doi: 10.1097/01.shk.0000180622.52058.3a.
dc.identifier.otherDOI: 10.1097/01.shk.0000180622.52058.3a
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/399
dc.language.isoen
dc.publisherShock
dc.subject.meshTumor Necrosis Factor-alpha / metabolismen
dc.subject.meshTreatment Outcomeen
dc.subject.meshTime Factorsen
dc.subject.meshSepsis / metabolismen
dc.subject.meshROC Curveen
dc.subject.meshProtein Precursors / metabolismen
dc.subject.meshPostoperative Complicationsen
dc.subject.meshPilot Projectsen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshMacrophage Migration-Inhibitory Factors / physiologyen
dc.subject.meshMacrophage Migration-Inhibitory Factors / blooden
dc.subject.meshInterleukin-6 / metabolismen
dc.subject.meshInterleukin-10 / metabolismen
dc.subject.meshInflammationen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshCytokines / metabolismen
dc.subject.meshChemokine CCL2 / metabolismen
dc.subject.meshCardiac Surgical Procedures / adverse effectsen
dc.subject.meshCalcitonin Gene-Related Peptideen
dc.subject.meshCalcitonin / metabolismen
dc.subject.meshC-Reactive Protein / metabolismen
dc.subject.meshBacterial Infections / microbiologyen
dc.subject.meshBacterial Infections / immunologyen
dc.subject.meshAnti-Infective Agents / pharmacologyen
dc.subject.meshAgeden
dc.subject.meshAcute-Phase Reactionen
dc.titleMacrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery
dc.typeArticle
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