Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery
Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery
Data
2005
Autores
Mendonça-Filho, Hugo Tannus Furtado de
Gomes, Gleice Silva
Nogueira, Pedro Miguel Mattos
Fernandes, Marco Aurelio de Oliveira
Tura, Bernardo Rangel
Santos, Marisa
Castro-Faria-Neto, Hugo Caire
Journal Title
Journal ISSN
Volume Title
Publisher
Shock
Resumo
This prospective consecutive observational study describes the blood levels of macrophage migration inhibitory factor (MIF), other cytokines, and markers of acute-phase response in 49 consecutive patients who developed the clinical syndrome of sepsis after cardiac surgery. Before starting antimicrobial treatment, all patients underwent microbiologic screening, and blood samples were collected. These samples subsequently were assayed for MIF, macrophage chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and -10, procalcitonin (PCT), and C-reactive protein (CRP). Patients with positive cultures (n = 25) had a higher mortality (P = 0.046) and higher levels of MIF (P < 0.001) than those with negative cultures (n = 24). We could not detect significant difference between the groups concerning the levels of CRP, PCT, IL6, IL10, MCP-1, or TNF-alpha. MIF levels showed an area under receiver operator curve of 0.823 for the prediction of culture-proven bacterial infection, with the best cut-off value at 988.5 pg/mL. In conclusion, circulating levels of MIF could be indicated as a valuable marker of microbiologically documented sepsis in patients after cardiac surgery, which suggests that MIF may be prospectively explored as a useful diagnostic tool in this setting.
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Citação
de Mendonça-Filho HT, Gomes GS, Nogueira PM, Fernandes MA, Tura BR, Santos M, Castro-Faria-Neto HC. Macrophage migration inhibitory factor is associated with positive cultures in patients with sepsis after cardiac surgery. Shock. 2005 Oct;24(4):313-7. doi: 10.1097/01.shk.0000180622.52058.3a.