Social and economic impacts of congenital Zika syndrome in Brazil: Study protocol and rationale for a mixed-methods study
Social and economic impacts of congenital Zika syndrome in Brazil: Study protocol and rationale for a mixed-methods study
Data
2019
Autores
Kuper, Hannah
Lyra, Tereza Maciel
Moreira, Maria Elisabeth Lopes
Albuquerque, Maria do Socorro Veloso de
Araújo, Thália Velho Barreto de
Fernandes, Silke
Jofre-Bonet, Mireia
Larson, Heidi
Melo, Ana Paula Lopes de
Mendes, Corina Helena Figueira
Journal Title
Journal ISSN
Volume Title
Publisher
Wellcome Open Research
Resumo
Global concern broke out in late 2015 as thousands of children in
Brazil were born with microcephaly, which was quickly linked to
congenital infection with Zika virus (ZIKV). ZIKV is now known to cause
a wider spectrum of severe adverse outcomes—congenital Zika
syndrome (CZS)—and also milder impairments. This study aimed to
explore the social and economic impacts of CZS in Brazil. Data was
collected through mixed methods across two settings: Recife City and
Jaboatão dos Guararapes in Pernambuco State (the epicentre of the
epidemic), and the city of Rio de Janeiro (where reports of ZIKV infection and CZS were less frequent). Data was collected May 2017-
January 2018. Ethical standards were adhered to throughout the
research. In-depth qualitative interviews were conducted with:
mothers and other carers of children with CZS (approximately 30 per
setting), pregnant women (10-12 per setting), men and women of
child-bearing age (16-20 per setting), and health professionals (10-12
per setting). Thematic analysis was undertaken independently by
researchers from at least two research settings, and these were
shared for feedback.
A case-control study was undertaken to quantitatively explore social
and economic differences between caregivers of a child with CZS
(cases) and caregivers with an unaffected child (controls). We aimed to
recruit 100 cases and 100 controls per setting, from existing studies.
The primary caregiver, usually the mother, was interviewed using a
structured questionnaire to collect information on: depression,
anxiety, stress, social support, family quality of life, health care and
social service use, and costs incurred by families. Multivariable logistic
regression analyses were used to compare outcomes for cases and
controls. Costs incurred as a result of CZS were estimated from the
perspective of the health system, families and society. Modelling was
undertaken to estimate the total economic burden of CZS from those
three perspectives.
Description
Palavras-chave
Zika, Congenital Zika Syndrome, Economic, Social, Depression, Anxiety, Brazil
Citação
Kuper H, Lyra TM, Moreira MEL, de Albuquerque MDSV, de Araújo TVB, Fernandes S, Jofre-Bonet M, Larson H, Lopes de Melo AP, Mendes CHF, Moreira MCN, do Nascimento MAF, Penn-Kekana L, Pimentel C, Pinto M, Simas C, Valongueiro S. Social and economic impacts of congenital Zika syndrome in Brazil: Study protocol and rationale for a mixed-methods study. Wellcome Open Res. 2019 Sep 11;3:127. doi: 10.12688/wellcomeopenres.14838.2.