COVID-19 in patients with cardiac disease: Impact and variables associated with mortality in a cardiology center in Brazil
COVID-19 in patients with cardiac disease: Impact and variables associated with mortality in a cardiology center in Brazil
Data
2021
Autores
Paulino, Mariah Rodrigues
Moreira, José Alfredo de Sousa
Correia, Marcelo Goulart
Santos, Léo Rodrigo Abrahão dos
Duarte, Ingrid Paiva
Sabioni, Letícia Roberto
Mucillo, Fabiana Bergamin
Garrido, Rafael Quaresma
Pacheco, Stephan Lachtermacher
de Lorenzo, Andrea
Journal Title
Journal ISSN
Volume Title
Publisher
American Heart Journal Plus : Cardiology Research and Practice
Resumo
Background: Cardiovascular disease is associated with severe COVID-19. Our aim was to describe clinical and
laboratory features (including electrocardiographic and echocardiographic ones) and outcomes of patients with
cardiac disease hospitalized with COVID-19.
Methods: This is an observational retrospective study of consecutive adult patients admitted, between March and
September of 2020, with confirmed SARSCoV-2 infection. Data were collected as per the ISARIC case report form
and complemented with variables related to heart disease.
Results: One hundred twenty-one patients were included. Mean age was 60 SD 15.2 years and 80/121(66.1%)
were male. Two-thirds of the patients (80/121, 66.1%) had COVID-19 at the time of hospital admission and
COVID-19 was the reason for hospitalization in 42 (34.7%). Other reasons for hospital admission were acute
coronary syndrome (26%) and decompensated heart failure (14.8%). Chronic cardiac diseases were found in
106/121 (87.6%), mostly coronary artery disease (62%) or valve disease (33.9%). A transthoracic echocardio-
gram was performed in 93/121(76.8%) and enlarged cardiac chambers were found in 71% (66/93); admission
ECG was done in 93 cases (93/121, 76.8%), and 89.2% (83/93) were abnormal. Hospital-acquisition of COVID-
19 occurred in 20 (16.5%) of patients and their mortality was 50%. On bivariate analysis for mortality, BNP
levels and troponin levels were NOT associated with mortality. On multivariate analysis, only C reactive protein
levels and creatinine levels were significant.
Conclusions: COVID-19 impacted the profile of hospital admissions in cardiac patients. BNP and troponin levels
were not associated with mortality and may not be good prognostic discriminators in cardiac patients.
Description
Palavras-chave
Coronavirus, COVID-19, Cardiac disease, Cardiac surgery, Hospitalization, Mortality
Citação
Paulino MR, Moreira JAS, Correia MG, Dos Santos LRA, Duarte IP, Sabioni LR, Mucillo FB, Garrido RQ, Pacheco SL, de Lorenzo A, Lamas CDC. COVID-19 in patients with cardiac disease: Impact and variables associated with mortality in a cardiology center in Brazil. Am Heart J Plus. 2021 Dec;12:100069. doi: 10.1016/j.ahjo.2021.100069.