Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)
Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)
Data
2023
Autores
Sabioni, Letícia
Lorenzo, Andrea De
Castro-Faria-Neto, Hugo Caire
Estato, Vanessa
Tibiriçá, Eduardo
Journal Title
Journal ISSN
Volume Title
Publisher
Brazilian Journal of Infectious Diseases
Resumo
Systemic microvascular dysfunction has been shown to be present in COVID-19, and serum
cytokines are known to be involved in the regulation of vascular function. We sought to eval-
uate systemic microvascular endothelial function, with laser doppler perfusion monitoring
(LDPM), and plasma levels of cytokines after acute COVID-19. Individuals admitted to a Cardi-
ology hospital with acute COVID-19 and followed for 12−15 months after recovery under-
went noninvasive evaluation of systemic endothelium-dependent microvascular reactivity
by cutaneous LDPM with local thermal hyperemia (LTH). A multiplex biometric immunoas-
say panel was used to assess 48 serum cytokines and chemokines. Twenty patients and 14
control volunteers were enrolled. The areas under the curves of vasodilation induced by LTH
were significantly increased after recovery (P=0.009) and were not different from values
obtained in healthy volunteers (P = 0.85). The peak microvascular flow during LTH did also
significantly increase (P = 0.02), and was not different form values obtained in healthy volun-
teers (P = 0.55). Several cytokines displayed significantly reduced serum concentrations after
recovery from COVID-19. In conclusion, endothelium-dependent systemic microvascular
reactivity improved after recovery from COVID-19 in patients with cardiovascular diseases,
in parallel with a reduction in the levels of several serum cytokines and chemokines involved
in the regulation of vascular function and inflammation.
Description
Palavras-chave
Laser Doppler perfusion monitoring, COVID-19, Endothelial dysfunction, Cytokines.
Citação
Sabioni L, De Lorenzo A, Castro-Faria-Neto HC, Estato V, Tibirica E. Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19). Braz J Infect Dis. 2023 Jan-Feb;27(1):102719. doi: 10.1016/j.bjid.2022.102719.