Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)

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dc.contributor.authorSabioni, Letícia
dc.contributor.authorLorenzo, Andrea De
dc.contributor.authorCastro-Faria-Neto, Hugo Caire
dc.contributor.authorEstato, Vanessa
dc.contributor.authorTibiriçá, Eduardo
dc.date.accessioned2025-07-30T18:24:43Z
dc.date.available2025-07-30T18:24:43Z
dc.date.issued2023
dc.description.abstractSystemic microvascular dysfunction has been shown to be present in COVID-19, and serum cytokines are known to be involved in the regulation of vascular function. We sought to eval- uate systemic microvascular endothelial function, with laser doppler perfusion monitoring (LDPM), and plasma levels of cytokines after acute COVID-19. Individuals admitted to a Cardi- ology hospital with acute COVID-19 and followed for 12−15 months after recovery under- went noninvasive evaluation of systemic endothelium-dependent microvascular reactivity by cutaneous LDPM with local thermal hyperemia (LTH). A multiplex biometric immunoas- say panel was used to assess 48 serum cytokines and chemokines. Twenty patients and 14 control volunteers were enrolled. The areas under the curves of vasodilation induced by LTH were significantly increased after recovery (P=0.009) and were not different from values obtained in healthy volunteers (P = 0.85). The peak microvascular flow during LTH did also significantly increase (P = 0.02), and was not different form values obtained in healthy volun- teers (P = 0.55). Several cytokines displayed significantly reduced serum concentrations after recovery from COVID-19. In conclusion, endothelium-dependent systemic microvascular reactivity improved after recovery from COVID-19 in patients with cardiovascular diseases, in parallel with a reduction in the levels of several serum cytokines and chemokines involved in the regulation of vascular function and inflammation.
dc.identifier.citationSabioni L, De Lorenzo A, Castro-Faria-Neto HC, Estato V, Tibirica E. Long-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19). Braz J Infect Dis. 2023 Jan-Feb;27(1):102719. doi: 10.1016/j.bjid.2022.102719.
dc.identifier.otherDOI: 10.1016/j.bjid.2022.102719
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/929
dc.language.isoen
dc.publisherBrazilian Journal of Infectious Diseases
dc.subjectLaser Doppler perfusion monitoringen
dc.subjectCOVID-19en
dc.subjectEndothelial dysfunctionen
dc.subjectCytokines.en
dc.titleLong-term assessment of systemic microcirculatory function and plasma cytokines after coronavirus disease 2019 (COVID-19)
dc.typeArticle
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