Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study
Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study
Data
2023
Autores
Escobar, Silas
Peçanha, Daniela
Duque, Maíra
Duque, Alice
Crahim, Vinícius
Lorenzo, Andrea de
Tibiriçá, Eduardo
Journal Title
Journal ISSN
Volume Title
Publisher
Microvascular Research
Resumo
Background: Metabolically healthy obesity (MHO), a phenotype of obesity considered to be of lower cardio-
vascular risk, is still a controversial concept. This study aimed to investigate the presence of subclinical systemic
microvascular dysfunction in individuals with MHO.
Methods: This was a cross-sectional study in which 112 volunteers were allocated into three groups: metabolically
healthy normal weight (MHNW), MHO, or metabolically unhealthy obesity (MUO). Obesity was defined as a
body mass index (BMI) ≥ 30 kg/m2
. MHO was defined as the absence of any component of metabolic syndrome,
except waist circumference. Microvascular reactivity was evaluated using cutaneous laser speckle contrast
imaging.
Results: Mean age was 33.2 ± 7.66 years. The median BMI in the MHNW, MHO and MUO groups was 23.6, 32.8,
and 35.8 kg/m2, respectively. Baseline microvascular conductance values were lower in the MUO group (0.25 ±
0.08 APU/mmHg) than in MHO (0.30 ± 0.10 APU/mmHg) and MHNW groups (0.33 ± 0.12 APU/mmHg) (P =
0.0008). There were no significant differences regarding endothelial-dependent (acetylcholine stimulation or
postocclusive reactive hyperemia) or endothelial-independent (sodium nitroprusside stimulation) microvascular
reactivity among the groups.
Conclusions: Individuals with MUO had lower baseline systemic microvascular flow than those with MHNW or
MHO, but endothelium-dependent or endothelium-independent microvascular reactivity were not changed in
any of the groups. The relatively young age of the study population, the low frequency of class III obesity, or the
strict definition of MHO (absence of any metabolic syndrome criteria) might account for the lack of difference of
microvascular reactivity among MHNW, MHO or MUO.
Description
Palavras-chave
Obesity, Metabolically healthy, Laser speckle contrast imaging, Microvascular function.
Citação
Escobar S, Peçanha D, Duque M, Duque A, Crahim V, De Lorenzo A, Tibirica E. Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study. Microvasc Res. 2023 Jul;148:104553. doi: 10.1016/j.mvr.2023.104553.