Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study

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dc.contributor.authorEscobar, Silas
dc.contributor.authorPeçanha, Daniela
dc.contributor.authorDuque, Maíra
dc.contributor.authorDuque, Alice
dc.contributor.authorCrahim, Vinícius
dc.contributor.authorLorenzo, Andrea de
dc.contributor.authorTibiriçá, Eduardo
dc.date.accessioned2025-07-30T18:09:37Z
dc.date.available2025-07-30T18:09:37Z
dc.date.issued2023
dc.description.abstractBackground: Metabolically healthy obesity (MHO), a phenotype of obesity considered to be of lower cardio- vascular risk, is still a controversial concept. This study aimed to investigate the presence of subclinical systemic microvascular dysfunction in individuals with MHO. Methods: This was a cross-sectional study in which 112 volunteers were allocated into three groups: metabolically healthy normal weight (MHNW), MHO, or metabolically unhealthy obesity (MUO). Obesity was defined as a body mass index (BMI) ≥ 30 kg/m2 . MHO was defined as the absence of any component of metabolic syndrome, except waist circumference. Microvascular reactivity was evaluated using cutaneous laser speckle contrast imaging. Results: Mean age was 33.2 ± 7.66 years. The median BMI in the MHNW, MHO and MUO groups was 23.6, 32.8, and 35.8 kg/m2, respectively. Baseline microvascular conductance values were lower in the MUO group (0.25 ± 0.08 APU/mmHg) than in MHO (0.30 ± 0.10 APU/mmHg) and MHNW groups (0.33 ± 0.12 APU/mmHg) (P = 0.0008). There were no significant differences regarding endothelial-dependent (acetylcholine stimulation or postocclusive reactive hyperemia) or endothelial-independent (sodium nitroprusside stimulation) microvascular reactivity among the groups. Conclusions: Individuals with MUO had lower baseline systemic microvascular flow than those with MHNW or MHO, but endothelium-dependent or endothelium-independent microvascular reactivity were not changed in any of the groups. The relatively young age of the study population, the low frequency of class III obesity, or the strict definition of MHO (absence of any metabolic syndrome criteria) might account for the lack of difference of microvascular reactivity among MHNW, MHO or MUO.
dc.identifier.citationEscobar S, Peçanha D, Duque M, Duque A, Crahim V, De Lorenzo A, Tibirica E. Evaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study. Microvasc Res. 2023 Jul;148:104553. doi: 10.1016/j.mvr.2023.104553.
dc.identifier.otherDOI: 10.1016/j.mvr.2023.104553
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/928
dc.language.isoen
dc.publisherMicrovascular Research
dc.subjectObesityen
dc.subjectMetabolically healthyen
dc.subjectLaser speckle contrast imagingen
dc.subjectMicrovascular function.en
dc.titleEvaluation of systemic endothelial-dependent and endothelial-independent microvascular reactivity in metabolically healthy obesity: An observational study
dc.typeArticle
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