Predictors of high-quality cord blood units
Predictors of high-quality cord blood units
Data
2016
Autores
Santos, Sandra V.F.
Barros, Sonia M.O.
Santos, Marisa S.
Marti, Luciana C.
Ribeiro, Andreza A.F.
Kondo, Andrea T.
Kutner, Jose M.
Journal Title
Journal ISSN
Volume Title
Publisher
Transfusion
Resumo
BACKGROUND: Analysis of umbilical cord blood
(UCB) transplants shows a correlation between
engraftment and total number of infused cells. Thus, it is
worth evaluating what maternal and neonatal
characteristics and collection techniques may affect the
quality of UCB units.
STUDY DESIGN AND METHODS: A cross-sectional
study was performed with 7897 donors sequentially
selected in three health care institutions in Brazil from
October 2004 to March 2012, in which both quantitative
and qualitative approaches were applied. All donors were
considered suitable for cord blood collection.
RESULTS: The maternal and neonatal characteristics
and techniques of collection that influenced the total
number of nucleated cells (TNCs; p < 0.001) were type of
delivery, newborn weight and sex, and institution of UCB
collection. The TNC count was associated with
gestational age (p 5 0.008), type of delivery (p < 0.001),
newborn sex (p < 0.001), newborn weight (p < 0.001),
and UCB collection technique (p 5 0.003). Center B
presented the largest number of nucleated cells in its
results (p < 0.001), followed by Center A (p 5 0.001).
Other characteristics, such as maternal age, were
analyzed but were not relevant for the nucleated cell
number.
CONCLUSION: This study provides elements for a
model that allows an efficient selection of UCB donors,
prioritizing candidates who have a better chance to lead
to an optimized use of cord blood cells units.
Description
Palavras-chave
Adult, Blood Banking / methods, Blood Preservation / methods, Blood Specimen Collection / methods*, Cross-Sectional Studies, Female, Fetal Blood / cytology*, Fetal Blood / physiology*, Gestational Age, Humans, Infant, Newborn, Male, Pregnancy
Citação
Santos SV, Barros SM, Santos MS, Marti LC, Ribeiro AA, Kondo AT, Kutner JM. Predictors of high-quality cord blood units. Transfusion. 2016 Aug;56(8):2030-6. doi: 10.1111/trf.13653.