Predictors of high-quality cord blood units

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dc.contributor.authorSantos, Sandra V.F.
dc.contributor.authorBarros, Sonia M.O.
dc.contributor.authorSantos, Marisa S.
dc.contributor.authorMarti, Luciana C.
dc.contributor.authorRibeiro, Andreza A.F.
dc.contributor.authorKondo, Andrea T.
dc.contributor.authorKutner, Jose M.
dc.date.accessioned2024-11-01T16:31:54Z
dc.date.available2024-11-01T16:31:54Z
dc.date.issued2016
dc.description.abstractBACKGROUND: Analysis of umbilical cord blood (UCB) transplants shows a correlation between engraftment and total number of infused cells. Thus, it is worth evaluating what maternal and neonatal characteristics and collection techniques may affect the quality of UCB units. STUDY DESIGN AND METHODS: A cross-sectional study was performed with 7897 donors sequentially selected in three health care institutions in Brazil from October 2004 to March 2012, in which both quantitative and qualitative approaches were applied. All donors were considered suitable for cord blood collection. RESULTS: The maternal and neonatal characteristics and techniques of collection that influenced the total number of nucleated cells (TNCs; p < 0.001) were type of delivery, newborn weight and sex, and institution of UCB collection. The TNC count was associated with gestational age (p 5 0.008), type of delivery (p < 0.001), newborn sex (p < 0.001), newborn weight (p < 0.001), and UCB collection technique (p 5 0.003). Center B presented the largest number of nucleated cells in its results (p < 0.001), followed by Center A (p 5 0.001). Other characteristics, such as maternal age, were analyzed but were not relevant for the nucleated cell number. CONCLUSION: This study provides elements for a model that allows an efficient selection of UCB donors, prioritizing candidates who have a better chance to lead to an optimized use of cord blood cells units.
dc.identifier.citationSantos SV, Barros SM, Santos MS, Marti LC, Ribeiro AA, Kondo AT, Kutner JM. Predictors of high-quality cord blood units. Transfusion. 2016 Aug;56(8):2030-6. doi: 10.1111/trf.13653.
dc.identifier.otherDOI: 10.1111/trf.13653
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/576
dc.language.isoen
dc.publisherTransfusion
dc.subjectAdulten
dc.subjectBlood Banking / methodsen
dc.subjectBlood Preservation / methodsen
dc.subjectBlood Specimen Collection / methods*en
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectFetal Blood / cytology*en
dc.subjectFetal Blood / physiology*en
dc.subjectGestational Ageen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectPregnancyen
dc.titlePredictors of high-quality cord blood units
dc.typeArticle
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