The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
Data
2020
Autores
Pereira, Marcos
Paixão, Enny
Trajman, Anete
Souza, Ramon Andrade de
Natividade, Marcio Santos da
Pescarini, Julia M.
Pereira, Susan Martins
Barreto, Florisneide Rodrigues
Ximenes, Ricardo
Dalcomo, Margareth
Journal Title
Journal ISSN
Volume Title
Publisher
Respiratory Research
Resumo
Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.
Description
Palavras-chave
BCG Vaccine / immunology*, BCG Vaccine / therapeutic use*, COVID-19, Clinical Trials as Topic, Coronavirus Infections / mortality, Coronavirus Infections / prevention & control*, Coronavirus Infections / therapy*, Cost-Benefit Analysis, Female, Humans, Male, Needs Assessment, Pandemics / prevention & control*, Pneumonia, Viral / mortality, Pneumonia, Viral / prevention & control*, Pneumonia, Viral / therapy*, Poverty, Primary Prevention / methods, Quality Control*, Role, Socioeconomic Factors, Survival Analysis, Vaccination / methods, Vaccination / statistics & numerical data.
Citação
Pereira M, Paixão E, Trajman A, de Souza RA, da Natividade MS, Pescarini JM, Pereira SM, Barreto FR, Ximenes R, Dalcomo M, Ichihara MY, Nunes C, Barral-Netto M, Barreto ML. The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19. Respir Res. 2020 Jul 11;21(1):178. doi: 10.1186/s12931-020-01439-4.