Systemic oxidative stress in victims of Bothrops snakebites

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dc.contributor.authorStrapazzon, Juliana de Ornellas
dc.contributor.authorParisotto, Eduardo Benedetti
dc.contributor.authorMoratelli, Ana Maria
dc.contributor.authorGarlet, Thais Regina
dc.contributor.authorBastos, Juliana
dc.contributor.authorZimermann, Ivan Ricardo
dc.contributor.authorZanin, Marlene
dc.contributor.authorFagundez, Rodrigo
dc.contributor.authorLino, Manuel Rosa de Oliveira
dc.contributor.authorFröde, Tânia Silvia
dc.contributor.authorFilho, Danilo Wilhelm
dc.date.accessioned2024-11-14T11:31:41Z
dc.date.available2024-11-14T11:31:41Z
dc.date.issued2015
dc.description.abstractThe genus Bothrops is responsible for approximately 90% of snakebites in Brazil. In the present study biomarkers of oxidative stress (OS) were evaluated in the blood of victims of snakebites fromBothrops jararaca andBothrops jararacussu. Patientmonitoring started from the emergency entrance at the hospital up to 30 days, groups divided as follows: time 0 (t0), 24 hours (t24h), 7 days (t7d) and 30 days (t30d). The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and myeloperoxidase (MPO), as well as the contents of reduced glutathione (GSH), vitamin E, lipid peroxidation (TBARS), protein carbonyls (PC) were examined in blood. Initial determinations revealed increased CAT, GR and GPx activities and decreased SOD and GST activities together with the depletion of GSH contents, while markers of oxidative damage showed increased TBARS levels and decreased PC concentrations in victims of snakebite compared to controls (blood donors). Regarding the temporal effect, no statistical differences among the groupswere detected for the distinct parameters analyzed. The responses obtained in OS biomarkers in victims of snakebite compared to healthy subjects indicate that Bothrops envenomation promoted a pronounced and persistent systemic OS in the blood of those subjects.
dc.identifier.citationOrnellas Strapazzon J, Benedetti Parisotto E, Moratelli AM, Garlet TR, Bastos J, Zimermann IR, et al.. Systemic oxidative stress in victims of Bothrops snakebites. J Appl Biomed. 2015;13(2):161-167. doi: 10.1016/j.jab.2014.11.002.
dc.identifier.otherDOI: 10.1016/j.jab.2014.11.002
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/604
dc.language.isoen
dc.publisherJournal of Applied Biomedicine
dc.subjectSnakebitesen
dc.subjectBothropsen
dc.subjectOphidic accidentsen
dc.subjectInflammationen
dc.subjectOxidative stressen
dc.subjectAntioxidantsen
dc.titleSystemic oxidative stress in victims of Bothrops snakebites
dc.typeArticle
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