Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics

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dc.contributor.authorAzevedo, Fabiula Schwartz de
dc.contributor.authorAlmeida, Gabriela de Castro
dc.contributor.authorAzevedo, Bruno Alvares de
dc.contributor.authorAguilar, Ivan Fernney Ibanez
dc.contributor.authorAzevedo, Bruno Nieckele
dc.contributor.authorTeixeira, Pedro Soares
dc.contributor.authorCamargo, Gabriel Cordeiro
dc.contributor.authorCorreia, Marcelo Goulart
dc.contributor.authorNieckele, Angela Ourivio
dc.contributor.authorOliveira, Glaucia Maria Moraes
dc.date.accessioned2025-02-04T13:08:35Z
dc.date.available2025-02-04T13:08:35Z
dc.date.issued2024
dc.description.abstractAscending aortic aneurysm (AAoA) is a silent disease with high mortality; however, the factors associated with a worse prognosis are not completely understood. The objective of this observational, longitudinal, single-center study was to identify the hemodynamic patterns and their influence on AAoA growth using computational fluid dynamics (CFD), focusing on the effects of geometrical variations on aortic hemodynamics. Personalized anatomic models were obtained from angiotomography scans of 30 patients in two different years (with intervals of one to three years between them), of which 16 (53%) showed aneurysm growth (defined as an increase in the ascending aorta volume by 5% or more). Numerically determined velocity and pressure fields were compared with the outcome of aneurysm growth. Through a statistical analysis, hemodynamic characteristics were found to be associated with aneurysm growth: average and maximum high pressure (superior to 100 Pa); average and maximum high wall shear stress (superior to 7 Pa) combined with high pressure (>100 Pa); and stress load over time (maximum pressure multiplied by the time interval between the exams). This study provides insights into a worse prognosis of this serious disease and may collaborate for the expansion of knowledge about mechanobiology in the progression of AAoA.
dc.identifier.citationde Azevedo FS, Almeida GC, Alvares de Azevedo B, Ibanez Aguilar IF, Azevedo BN, Teixeira PS, Camargo GC, Correia MG, Nieckele AO, Oliveira GMM. Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics. Bioengineering (Basel). 2024 Feb 22;11(3):204. doi: 10.3390/bioengineering11030204.
dc.identifier.otherDOI: 10.3390/bioengineering11030204
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/783
dc.language.isoen
dc.publisherBioengineering
dc.subjectAscending aortic aneurysmen
dc.subjectcomputational fluid dynamicsen
dc.subjectwall shear stressen
dc.subjectwall pressure.en
dc.titleStress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics
dc.typeArticle
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