Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics
Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics
Data
2024
Autores
Azevedo, Fabiula Schwartz de
Almeida, Gabriela de Castro
Azevedo, Bruno Alvares de
Aguilar, Ivan Fernney Ibanez
Azevedo, Bruno Nieckele
Teixeira, Pedro Soares
Camargo, Gabriel Cordeiro
Correia, Marcelo Goulart
Nieckele, Angela Ourivio
Oliveira, Glaucia Maria Moraes
Journal Title
Journal ISSN
Volume Title
Publisher
Bioengineering
Resumo
Ascending aortic aneurysm (AAoA) is a silent disease with high mortality; however, the
factors associated with a worse prognosis are not completely understood. The objective of this
observational, longitudinal, single-center study was to identify the hemodynamic patterns and their
influence on AAoA growth using computational fluid dynamics (CFD), focusing on the effects of
geometrical variations on aortic hemodynamics. Personalized anatomic models were obtained from
angiotomography scans of 30 patients in two different years (with intervals of one to three years
between them), of which 16 (53%) showed aneurysm growth (defined as an increase in the ascending
aorta volume by 5% or more). Numerically determined velocity and pressure fields were compared
with the outcome of aneurysm growth. Through a statistical analysis, hemodynamic characteristics
were found to be associated with aneurysm growth: average and maximum high pressure (superior
to 100 Pa); average and maximum high wall shear stress (superior to 7 Pa) combined with high
pressure (>100 Pa); and stress load over time (maximum pressure multiplied by the time interval
between the exams). This study provides insights into a worse prognosis of this serious disease and
may collaborate for the expansion of knowledge about mechanobiology in the progression of AAoA.
Description
Palavras-chave
Ascending aortic aneurysm, computational fluid dynamics, wall shear stress, wall pressure.
Citação
de Azevedo FS, Almeida GC, Alvares de Azevedo B, Ibanez Aguilar IF, Azevedo BN, Teixeira PS, Camargo GC, Correia MG, Nieckele AO, Oliveira GMM. Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics. Bioengineering (Basel). 2024 Feb 22;11(3):204. doi: 10.3390/bioengineering11030204.