Added Value of QuantiFERON TB-Gold in-Tube for Detecting Latent Tuberculosis Infection among Persons Living with HIV/AIDS

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dc.contributor.authorSouza, Josiane Maria Oliveira
dc.contributor.authorEvangelista, Maria do Socorro Nantua
dc.contributor.authorTrajman, Anete
dc.date.accessioned2025-01-03T14:43:20Z
dc.date.available2025-01-03T14:43:20Z
dc.date.issued2014
dc.description.abstractObjective. To evaluate the added value of QuantiFERON TB-Gold in-Tube (QTF-GIT) over the tuberculin skin testing (TST) for detecting latent tuberculosis (TB) infection (LTBI) among patients with AIDS in a city with a low TB incidence rate (11.1/100,000 inhabitants) and universal BCG coverage. Methods. Three hundred consecutive patients with AIDS in eight outpatient sexually transmitted disease public clinics in Brasilia were submitted to QFT-IT and TST between May 2011 and March 2013. A positive result of either test was considered to be LTBI. Results. Median CD4-cell count was 477.5 cells/mm3 ; 295 (98.3%) were using antiretroviral therapy. Eighteen patients (6%, 95% CI: 3.6%–9.3%) had LTBI, of whom 4 (1.3%, 95% CI: 0.04%–2.63%) had only a positive TST, 8 (2.7%, 95% CI: 0.8%–4.5%) had only a QFT-GIT positive test, and 6 (2%, 95% CI: 0.4%–3.6%) had positive results for both tests. This represents an 81.8% relative increase in LTBI detection when QFT-GIT is added to TST. The concordance between both tests was 96% (k = 0.48). Conclusions. The QFT-GIT alone was more effective to detect LTBI than TST alone and had an 81% added value as an add-on sequential test in this population with mild immunosuppression. The cost-effectiveness of these strategies remains to be evaluated.
dc.identifier.citationSouza JM, Evangelista Mdo S, Trajman A. Added value of QuantiFERON TB-gold in-tube for detecting latent tuberculosis infection among persons living with HIV/AIDS. Biomed Res Int. 2014;2014:294963. doi: 10.1155/2014/294963. Epub 2014 May 29.
dc.identifier.otherDOI: 10.1155/2014/294963
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/735
dc.language.isoen
dc.publisherBioMed Research International
dc.subjectAcquired Immunodeficiency Syndrome / complicationsen
dc.subjectAcquired Immunodeficiency Syndrome / microbiologyen
dc.subjectAcquired Immunodeficiency Syndrome / pathology*en
dc.subjectAdulten
dc.subjectCD4 Lymphocyte Count
dc.subjectFemale
dc.subjectHumans
dc.subjectInterferon-gamma Release Tests
dc.subjectLatent Tuberculosis / complications
dc.subjectLatent Tuberculosis / diagnosis*
dc.subjectLatent Tuberculosis / pathology*
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectTuberculin Test / methods*
dc.titleAdded Value of QuantiFERON TB-Gold in-Tube for Detecting Latent Tuberculosis Infection among Persons Living with HIV/AIDS
dc.typeArticle
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