Added Value of QuantiFERON TB-Gold in-Tube for Detecting Latent Tuberculosis Infection among Persons Living with HIV/AIDS
Added Value of QuantiFERON TB-Gold in-Tube for Detecting Latent Tuberculosis Infection among Persons Living with HIV/AIDS
Data
2014
Autores
Souza, Josiane Maria Oliveira
Evangelista, Maria do Socorro Nantua
Trajman, Anete
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Research International
Resumo
Objective. To evaluate the added value of QuantiFERON TB-Gold in-Tube (QTF-GIT) over the tuberculin skin testing (TST) for
detecting latent tuberculosis (TB) infection (LTBI) among patients with AIDS in a city with a low TB incidence rate (11.1/100,000
inhabitants) and universal BCG coverage. Methods. Three hundred consecutive patients with AIDS in eight outpatient sexually
transmitted disease public clinics in Brasilia were submitted to QFT-IT and TST between May 2011 and March 2013. A positive result
of either test was considered to be LTBI. Results. Median CD4-cell count was 477.5 cells/mm3
; 295 (98.3%) were using antiretroviral
therapy. Eighteen patients (6%, 95% CI: 3.6%–9.3%) had LTBI, of whom 4 (1.3%, 95% CI: 0.04%–2.63%) had only a positive TST,
8 (2.7%, 95% CI: 0.8%–4.5%) had only a QFT-GIT positive test, and 6 (2%, 95% CI: 0.4%–3.6%) had positive results for both tests.
This represents an 81.8% relative increase in LTBI detection when QFT-GIT is added to TST. The concordance between both tests
was 96% (k = 0.48). Conclusions. The QFT-GIT alone was more effective to detect LTBI than TST alone and had an 81% added value
as an add-on sequential test in this population with mild immunosuppression. The cost-effectiveness of these strategies remains to
be evaluated.
Description
Palavras-chave
Acquired Immunodeficiency Syndrome / complications, Acquired Immunodeficiency Syndrome / microbiology, Acquired Immunodeficiency Syndrome / pathology*, Adult, CD4 Lymphocyte Count, Female, Humans, Interferon-gamma Release Tests, Latent Tuberculosis / complications, Latent Tuberculosis / diagnosis*, Latent Tuberculosis / pathology*, Male, Middle Aged, Tuberculin Test / methods*
Citação
Souza JM, Evangelista Mdo S, Trajman A. Added value of QuantiFERON TB-gold in-tube for detecting latent tuberculosis infection among persons living with HIV/AIDS. Biomed Res Int. 2014;2014:294963. doi: 10.1155/2014/294963. Epub 2014 May 29.