Prevalence of high HbA1c levels in Brazilian adolescents: The Study of Cardiovascular Risk in Adolescents
Prevalence of high HbA1c levels in Brazilian adolescents: The Study of Cardiovascular Risk in Adolescents
Data
2017
Autores
Fernandes, Rita de Cássia Lima
Teló, Gabriela H.
Cureau, Felipe V.
Barufaldi, Laura A.
Kuschnir, Maria Cristina C.
Schaan, Beatriz D.
Szklo, Moyses
Bloch, Katia V.
Journal Title
Journal ISSN
Volume Title
Publisher
Diabetes Research and Clinical Practice
Resumo
To evaluate the prevalence of elevated glycated haemoglobin (HbA1c) levels in a pop-
ulation of adolescents participating in the Study of Cardiovascular Risk in Adolescents.
Methods: This is a school-based cross-sectional study based on a complex sample of ado-
lescents 12–17 years old representative at the national and macro-regional levels and for
each Brazilian state capital. Blood was collected in schools and then evaluated in a single
laboratory. HbA1c levels were considered elevated if P5.7% (39 mmol/mol) and were ana-
lyzed according to sex, age, macro-region, type of school, skin color, and nutritional status.
Results: Data from 37,804 adolescents were analyzed. The mean level of HbA1c was 5.4%
(95%CI 5.4–5.4) (36 mmol/mol [95%CI 36–36]), and 20.5% (95%CI 19.1–22.0) of adolescents
presented values P5.7% (P39 mmol/mol). Among males, 23.6% (95%CI 21.8–25.6) showed
elevated HbA1c levels compared to 17.5% (95%CI 15.9–19.2) observed in females. The preva-
lence of elevated levels of HbA1c was higher in adolescents with black skin color (27.6%;
95%CI 23.2–32.4) vs. white skin color (16.9%; 95%CI 15.4–18.5), and higher in those who stud-
ied in public schools (21.6%; 95%CI 20.0–23.4) vs. private schools (16.7%; 95%CI 14.7–19.0).
Among obese adolescents, 29.7% (95%CI 25.4–34.3) had elevated levels of HbA1c, compared
to 19.3% (95%CI 18.0–20.7) in normal weight students and 19.7% (95%CI 17.1–22.6) in over-
weight adolescents.
Conclusions: Obese male adolescents of lower socioeconomic status had a higher preva-
lence of elevated HbA1c levels. Our findings highlight the importance of focusing on this
high risk group for interventions to prevent diabetes.
Description
Palavras-chave
Adolescent, Hemoglobin A, glycosylated, Obesity, Diabetes mellitus, Developing countries
Citação
Fernandes RCL, Teló GH, Cureau FV, Barufaldi LA, Kuschnir MC, Schaan BD, Szklo M, Bloch KV. Prevalence of high HbA1c levels in Brazilian adolescents: The Study of Cardiovascular Risk in Adolescents. Diabetes Res Clin Pract. 2017 Mar;125:1-9. doi: 10.1016/j.diabres.2017.01.003