Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia

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dc.contributor.authorMoll, Jorge
dc.contributor.authorZahn, Roland
dc.contributor.authorOliveira-Souza, Ricardo de
dc.contributor.authorBramati, Ivanei E.
dc.contributor.authorKrueger, Frank
dc.contributor.authorTura, Bernardo
dc.contributor.authorCavanagh, Alyson L.
dc.contributor.authorGrafman, Jordan
dc.date.accessioned2023-12-06T17:31:42Z
dc.date.available2023-12-06T17:31:42Z
dc.date.issued2011
dc.description.abstractPoets and philosophers have long acknowledged moral sentiments as key motivators of human social behavior. Prosocial sentiments, which include guilt, pity and embarrassment, enable us to care about others and to be concerned about our mistakes. Functional imaging studies have implicated frontopolar, ventromedial frontal and basal forebrain regions in the experience of prosocial sentiments. Patients with lesions of the frontopolar and ventromedial frontal areas were observed to behave inappropriately and less prosocially, which could be attributed to a generalized emotional blunting. Direct experimental evidence for brain regions distinctively associated with moral sentiment impairments is lacking, however. We investigated this issue in patients with the behavioral variant of frontotemporal dementia, a disorder in which early and selective impairments of social conduct are consistently observed. Using a novel moral sentiment task, we show that the degree of impairment of prosocial sentiments is associated with the degree of damage to frontopolar cortex and septal area, as assessed with 18-Fluoro-Deoxy-Glucose-Positron Emission Tomography, an established measure of neurodegenerative damage. This effect was dissociable from impairment of other-critical feelings (anger and disgust), which was in turn associated with dorsomedial prefrontal and amygdala dysfunction. Our findings suggest a critical role of the frontopolar cortex and septal region in enabling prosocial sentiments, a fundamental component of moral conscience
dc.identifier.citationMoll J, Zahn R, de Oliveira-Souza R, Bramati IE, Krueger F, Tura B, Cavanagh AL, Grafman J. Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia. Neuroimage. 2011 Jan 15;54(2):1735-42. doi: 10.1016/j.neuroimage.2010.08.026. Epub 2010 Aug 20. PMID: 20728544; PMCID: PMC2997153.
dc.identifier.otherDOI: 10.1016/j.neuroimage.2010.08.026
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/376
dc.language.isoen
dc.publisherNeuroImage
dc.subjectEmotionen
dc.subjectAmygdalaen
dc.subjectSeptal areaen
dc.subjectSubgenualen
dc.subjectPrefrontal cortexen
dc.subjectFrontopolar cortexen
dc.subjectMoral sentimenten
dc.subjectOrbitofrontal cortexen
dc.subject.meshSocial Behavioren
dc.subject.meshPositron-Emission Tomographyen
dc.subject.meshNeuropsychological Testsen
dc.subject.meshMoralsen
dc.subject.meshImage Processing, Computer-Assisteden
dc.subject.meshHumansen
dc.subject.meshFrontotemporal Dementia / physiopathologyen
dc.subject.meshFrontotemporal Dementia / diagnostic imagingen
dc.subject.meshEmotions / physiologyen
dc.subject.meshBrain Mappingen
dc.subject.meshBrain / physiopathologyen
dc.subject.meshBrain / diagnostic imagingen
dc.titleImpairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia
dc.typeArticle
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