Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection

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dc.contributor.authorBastos, M. L.
dc.contributor.authorMenzies, D.
dc.contributor.authorBelo, M. T. C. T.
dc.contributor.authorTeixeira, E. G.
dc.contributor.authorAbreu, S. T. de
dc.contributor.authorAntas, P. R. Z.
dc.date.accessioned2024-12-09T19:42:57Z
dc.date.available2024-12-09T19:42:57Z
dc.date.issued2013
dc.description.abstractSETTING: Randomised trial comparing 9 months of isoniazid with 4 months of rifampicin for the treatment of high-risk tuberculin skin test positive subjects in Rio de Janeiro, Brazil. OBJECTIVES: To compare QuantiFERON®-TB Gold In- Tube (QFT-GIT) responses before and 1, 4 and 9 months after starting treatment for latent tuberculous infection (LTBI) according to adherence to one of the two regimens. DESIGN: Participants in the trial were invited to under- go serial QFT-GIT. Within-subject differences at differ- ent time points were analysed as quantitative responses and categorised as positive or negative using different cut-off points. RESULTS: Of 215 participants, 118 completed treat- ment, of whom 58 underwent all three tests; and 97 did not complete treatment, of whom 10 underwent all tests. After 1 month of treatment, there was no significant dif- ference in QFT-GIT response between the groups. After 4 and 9 months, reversions were more frequent in non- adherent subjects. Marked within-subject fluctuations were observed. No cut-off point could be established at which QFT-GIT responses were consistently positive or associated with adherence or type of treatment. CONCLUSION: Frequent within-subject variability in QFT-GIT responses, not associated with LTBI treatment, makes it difficult for clinicians to interpret QFT-GIT conversions and reversions.
dc.identifier.citationBastos ML, Menzies D, Belo MT, Teixeira EG, de Abreu ST, Antas PR, Trajman A. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. Int J Tuberc Lung Dis. 2013 Jul;17(7):909-16. doi: 10.5588/ijtld.12.0927.
dc.identifier.otherDOI: 10.5588/ijtld.12.0927
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/690
dc.language.isoen
dc.publisherInternational Journal of Tuberculosis and Lung Disease
dc.subjectbiomarkeren
dc.subjectinterferon-gamma assayen
dc.subjectserial testingen
dc.subjectlatent tuberculosis.en
dc.titleChanges in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
dc.typeArticle
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