Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
Data
2013
Autores
Bastos, M. L.
Menzies, D.
Belo, M. T. C. T.
Teixeira, E. G.
Abreu, S. T. de
Antas, P. R. Z.
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Tuberculosis and Lung Disease
Resumo
SETTING: Randomised trial comparing 9 months of
isoniazid with 4 months of rifampicin for the treatment
of high-risk tuberculin skin test positive subjects in Rio
de Janeiro, Brazil.
OBJECTIVES: To compare QuantiFERON®-TB Gold In-
Tube (QFT-GIT) responses before and 1, 4 and 9 months
after starting treatment for latent tuberculous infection
(LTBI) according to adherence to one of the two
regimens.
DESIGN: Participants in the trial were invited to under-
go serial QFT-GIT. Within-subject differences at differ-
ent time points were analysed as quantitative responses
and categorised as positive or negative using different
cut-off points.
RESULTS: Of 215 participants, 118 completed treat-
ment, of whom 58 underwent all three tests; and 97 did
not complete treatment, of whom 10 underwent all tests.
After 1 month of treatment, there was no significant dif-
ference in QFT-GIT response between the groups. After
4 and 9 months, reversions were more frequent in non-
adherent subjects. Marked within-subject fluctuations
were observed. No cut-off point could be established at
which QFT-GIT responses were consistently positive or
associated with adherence or type of treatment.
CONCLUSION: Frequent within-subject variability in
QFT-GIT responses, not associated with LTBI treatment,
makes it difficult for clinicians to interpret QFT-GIT
conversions and reversions.
Description
Palavras-chave
biomarker, interferon-gamma assay, serial testing, latent tuberculosis.
Citação
Bastos ML, Menzies D, Belo MT, Teixeira EG, de Abreu ST, Antas PR, Trajman A. Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection. Int J Tuberc Lung Dis. 2013 Jul;17(7):909-16. doi: 10.5588/ijtld.12.0927.