Diagnosis of blood culture‑negative endocarditis and clinical comparison between blood culture‑negative and blood culture‑positive cases

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dc.contributor.authorLamas, Cristiane C.
dc.contributor.authorFournier, · Pierre‑Edouard
dc.contributor.authorZappa, Monica
dc.contributor.authorBrandão, Tatiana J. D.
dc.contributor.authorSilva, Carolina A. Januário da
dc.contributor.authorCorreia, Marcelo G.
dc.contributor.authorBarbosa, Giovanna Ianini F.
dc.contributor.authorGolebiovski, Wilma F.
dc.contributor.authorWeksler, Clara
dc.contributor.authorLepid, Hubert
dc.contributor.authorRaoult, Didier
dc.date.accessioned2022-08-16T14:39:54Z
dc.date.available2022-08-16T14:39:54Z
dc.date.issued2016
dc.description.abstractPurpose To analyze the clinical characteristics of blood culture-negative endocarditis (BCNE) and how it compares to those of blood culture-positive endocarditis (BCPE) cases and show how molecular tools helped establish the etiology in BCNE. Methods Adult patients with definite infective endocarditis (IE) and having valve surgery were included. Valves were studied by polymerase chain reaction (PCR). Statistical analysis compared BCNE and BCPE. Results One hundred and thirty-one patients were included; 53 (40 %) had BCNE. The mean age was 45 ± 16 years; 33 (62 %) were male. BCNE was community-acquired in 41 (79 %). Most patients were referred from other hospitals (38, 73 %). Presentation was subacute in 34 (65 %), with fever in 47/53 (90 %) and a new regurgitant murmur in 34/42 (81 %). Native valves were affected in 74 %, mostly left-sided. All echocardiograms showed major criteria for IE. Antibiotics were used prior to BC collection in 31/42 (74 %). Definite histological diagnosis was established for 35/50 (70 %) valves. PCR showed oralis group streptococci in 21 (54 %), S. aureus in 3 (7.7 %), gallolyticus group streptococci in 2 (5.1 %), Coxiella burnetii in 1 (2.5 %) and Rhizobium sp. in 1 (2.5 %). Inhospital mortality was 9/53 (17 %). Fever (p = 0.06, OR 4.7, CI 0.91–24.38) and embolic complications (p = 0.003, OR 3.3, CI 1.55–6.82) were more frequent in BCPE cases, while new acute regurgitation (p = 0.05, OR 0.3, CI 0.098–0.996) and heart failure (p = 0.02, OR 0.3, CI 0.13– 0.79) were less so. Conclusions BCNE resulted mostly from prior antibiotics and was associated with severe hemodynamic compromise. Valve histopathology and PCR were useful in confirming the diagnosis and pointing to the etiology of BCNE.en
dc.identifier.citationLamas CC, Fournier P, zappa M, Brandão TJD, Silva, CAJ, Correia MG et al. Diagnosis of blood culture‑negative endocarditis and clinical comparison between blood culture‑negative and blood culture‑positive cases. Infection. 2016; 44: 459-466. Doi: 10.1007/s15010-015-0863-x.
dc.identifier.otherDOI: 10.1007/s15010-015-0863-x
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/102
dc.language.isoen
dc.publisherInfection
dc.subjectInfective endocarditisen
dc.subjectNegative blood culturesen
dc.subjectPolymerase chain reactionen
dc.subjectValve pathologyen
dc.subjectDiagnostic criteriaen
dc.subject.meshRetrospective Studiesen
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshHumansen
dc.subject.meshHeart Valves / microbiologyen
dc.subject.meshFemaleen
dc.subject.meshEndocarditis, Bacterial / microbiologyen
dc.subject.meshEndocarditis, Bacterial / epidemiologyen
dc.subject.meshEndocarditis, Bacterial / diagnosisen
dc.subject.meshDNA, Bacterial / geneticsen
dc.subject.meshDNA, Bacterial / analysisen
dc.subject.meshBlood Culture / statistics & numerical dataen
dc.subject.meshAdulten
dc.titleDiagnosis of blood culture‑negative endocarditis and clinical comparison between blood culture‑negative and blood culture‑positive casesen
dc.typeArticle
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