Systematic review on efficacy of preventive measures for surgical site infection by multiple-drug resistant gram-negative bacilli

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dc.contributor.authorMatos, Juliana Arruda de
dc.contributor.authorGomes, Amanda da Silva
dc.contributor.authorLima, Carla Ormundo G. Ximenes
dc.contributor.authorSchmaltz, Carolina Arana Stanis
dc.contributor.authorOliveira, Cristiane Rocha de
dc.contributor.authorSilva, Grasiela Martins da
dc.contributor.authorCarijó, Julia Herkenhoff
dc.contributor.authorLopes, Marielena Aguiar
dc.contributor.authorMorais, Quenia Cristina Dias
dc.contributor.authorBrasil, Pedro Emmanuel Alvarenga Americano do
dc.date.accessioned2024-03-05T14:54:35Z
dc.date.available2024-03-05T14:54:35Z
dc.date.issued2022
dc.description.abstractBackground: There are no specific recommendations for prevention of surgical site infection (SSI) caused by multidrug resistant Gram-negative bacilli (MDR-GNB). Our objective was to systematically review the literature evaluating the efficacy and safety of measures specifically designed to prevent MDR-GNB SSI. Methods: We searched MEDLINE, EMBASE, CINAHL and LILACS databases up to February 18, 2020. Randomized trials and observational cohort studies evaluating the efficacy of preventive measures against MDR-GNB SSI in adult surgical patients were eligible. We evaluated methodological quality of studies and general quality of evidence using Newcastle-Ottawa scale, Cochrane ROBINS-I and GRADE method. Random-effects meta-analyses were performed using Review Manager V.5.3 software. Results: A total of 10,663 titles by searching databases were identified. Two retrospective observational studies, comparing surgical antibiotic prophylaxis (SAP) with or without aminoglycoside in renal transplantation recipients, and one non-randomized prospective study, evaluating ertapenem vs. cephalosporin plus metronidazole for SAP in extended spectrum beta-lactamase producing Enterobacteriales carriers undergoing colon surgery, were included. Risk of bias was high in all studies. Meta-analysis was performed for the renal transplantation studies, with 854 patients included. Combined relative risk (RR) for MDR GNB SSI was 0.57 (95%CI: 0.25-1.34), favoring SAP with aminoglycoside (GRADE: moderate). Conclusions: There are no sufficient data supporting specific measures against MDR-GNB SSI. Prospective, randomized studies are necessary to assess the efficacy and safety of SAP with aminoglycoside for MDR-GNB SSI prevention among renal transplantation recipients and other populations. PROSPERO 2018 CRD42018100845. Keywords: Drug resistance, multiple; Gram-negative bacterial infections; Infection control; Surgical wound infection; Systematic review. Copyright © 2022 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.en
dc.identifier.citationMatos JA, Gomes As, Lima COG, Schmaltz CAS, Oliveira CR, Silva GM, Carijó JH, Lopes MA, Morais QCD, Brasil PEAA. Systematic review on efficacy of preventive measures for surgical site infection by multiple-drug resistant gram-negative bacilli. Braz J Infect Dis[Internet]. 2022;126(6):102705. doi: 10.1016/j.bjid.2022.102705.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/420
dc.language.isoen
dc.publisherThe Brazilian Journal of Infectious Diseases
dc.subjectSurgical wound infectionen
dc.subjectInfection controlen
dc.subjectGram-negative bacterial infectionsen
dc.subjectDrug resistance, multipleen
dc.subjectSystematic reviewen
dc.subjectInfecção da Ferida Cirúrgicapt_br
dc.subjectControle de Infecçõespt_br
dc.subjectInfecções por Bactérias Gram-Negativaspt_br
dc.subjectResistência a Múltiplos Medicamentospt_br
dc.subjectRevisão Sistemáticapt_br
dc.titleSystematic review on efficacy of preventive measures for surgical site infection by multiple-drug resistant gram-negative bacilli
dc.typeArticleen
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