Estimating an EQ‐5D‐Y‐3L Value Set for Brazil
Estimating an EQ‐5D‐Y‐3L Value Set for Brazil
Data
2024
Autores
Santo, Caique Melo Espirito
Miyamoto, Gisela Cristiane
Santos, Verônica Souza
Ben, Ângela Jornada
Finch, Aureliano Paolo
Roudijk, Bram
Jesus‐Moraleida, Fabianna Resende de
Stein, Airton Tetelbom
Santos, Marisa
Yamato, Tiê Parma
Journal Title
Journal ISSN
Volume Title
Publisher
PharmacoEconomics
Resumo
Introduction The EQ-5D-Y-3L is a generic measure of health-related quality of life in children and adolescents. Although
the Brazilian-Portuguese EQ-5D-Y-3L version is available, there is no value set for it, hampering its use in economic evalu-
ations. This study aimed to elicit a Brazilian EQ-5D-Y-3L value set based on preferences of the general adult population.
Methods Two independent samples of adults participated in an online discrete choice experiment (DCE) survey and a
composite time trade-of (cTTO) face-to-face interview. The framing was “considering your views for a 10-year-old child”.
DCE data were analyzed using a mixed-logit model. The 243 DCE predicted values were mapped into the observed 28 cTTO
values using linear and non-linear mapping approaches with and without intercept. Mapping approaches’ performance was
assessed to estimate the most valid method to rescale DCE predicted values using the model ft (R2
), Akaike Information
Criteria (AIC), root mean squared error (RMSE), and mean absolute error (MAE).
Results A representative sample of 1376 Brazilian adults participated (DCE, 1152; cTTO, 211). The linear mapping without
intercept (R2
= 96%; AIC, − 44; RMSE, 0.0803; MAE, − 0.0479) outperformed the non-linear without intercept (R2
= 98%;
AIC, − 63; RMSE, 0.1385; MAE, − 0.1320). Utilities ranged from 1 (full health) to − 0.0059 (the worst health state). High-
est weights were assigned to having pain or discomfort (pain/discomfort), followed by walking about (mobility), looking
after myself (self-care), doing usual activities (usual activities), and feeling worried, sad, or unhappy (anxiety/depression).
Conclusion This study elicited the Brazilian EQ-5D-Y-3L value set using a mixed-logit DCE model with a power parameter
based on a linear mapping without intercept, which can be used to estimate the quality-adjusted life-years for economic
evaluations of health technologies targeting the Brazilian youth population.
Description
Palavras-chave
Adolescent, Adult, Brazil, Child, Choice Behavior, Female, Health Status, Humans, Male, Middle Aged, Quality of Life*, Surveys and Questionnaires, Young Adult.
Citação
Espirito Santo CM, Miyamoto GC, Santos VS, Ben ÂJ, Finch AP, Roudijk B, de Jesus-Moraleida FR, Stein AT, Santos M, Yamato TP. Estimating an EQ-5D-Y-3L Value Set for Brazil. Pharmacoeconomics. 2024 Sep;42(9):1047-1063. doi: 10.1007/s40273-024-01404-9.