Systematic review of dengue vaccine efficacy

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dc.contributor.authorSilveira, Lucia Teresa Côrtes da
dc.contributor.authorTura, Bernardo
dc.contributor.authorSantos, Marisa
dc.date.accessioned2022-08-08T14:46:56Z
dc.date.available2022-08-08T14:46:56Z
dc.date.issued2019
dc.description.abstractBackground: Dengue is an arbovirus that has rapidly spread worldwide, and the incidence of dengue has greatly increased in recent decades. The actual numbers of dengue cases are underreported, and many cases are not classified correctly. Recent estimates indicate that 390 million dengue infections occur per year (95% CI, 284-528 million), of which 96 million (67-136 million) are symptomatic infections of any severity. One of the goals of the World Health Organization is to reduce dengue mortality by 50% by the year 2020. The use of a vaccine can be an important strategy to achieve this goal. Vaccines for dengue are in various stages of development; in Brazil, only one commercial formulation is available (CYD-TDV), which was developed by Sanofi Pasteur. Methods: To evaluate the efficacy of Dengue vaccine, a systematic review with a meta-analysis was conducted using randomized controlled clinical trials published between 2000 and 2017 that were identified in the MEDLINE databases via PubMed, LILACS, Cochrane Library, and EMBASE. The selection was performed by two reviewers independently, with disagreements resolved by a third reviewer. Results: Seven clinical trials were included, with a total of 36,371 participants (66,511 person-years) between the ages of 2 and 45 years. The meta-analysis using the random-effects model estimated the efficacy of the vaccine at 44%, with a range from 25 to 59% and high heterogeneity (I2 = 80.1%). The serotype-stratified meta-analysis was homogeneous, except for serotype 2, with the heterogeneity of 64.5%. Most of the vaccinated individuals had previous immunity for at least one serotype, which generated safety concerns in individuals without previous immunity. Conclusions: Compared with other commercially available vaccines, the dengue vaccine showed poor efficacy.en
dc.identifier.citationda Silveira LTC, Tura B, Santos M. Systematic review of dengue vaccine efficacy. BMC Infect Dis. 2019 Aug 28;19(1):750. Doi: 10.1186/s12879-019-4369-5
dc.identifier.otherDOI: 10.1186/s12879-019-4369-5
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/63
dc.language.isoen
dc.publisherBMC Infectious Diseases
dc.subjectDengueen
dc.subjectDengue vaccinesen
dc.subjectDengue - vacinaspt
dc.subjectDengue virusen
dc.subjectDengue - víruspt
dc.subjectHealth technology assessmenten
dc.subjectAvaliação de Tecnologias em Saúdept
dc.subjectSystematic reviewen
dc.subjectRevisão sistemáticapt
dc.subject.meshSerogroupen
dc.subject.meshRandomized Controlled Trials as Topicen
dc.subject.meshMiddle Ageden
dc.subject.meshHumansen
dc.subject.meshDengue Vaccines / pharmacologyen
dc.subject.meshDengue Vaccines / immunologyen
dc.subject.meshDengue / prevention & controlen
dc.subject.meshDengue / immunologyen
dc.subject.meshChild, Preschoolen
dc.subject.meshChilden
dc.subject.meshBrazilen
dc.subject.meshAdulten
dc.subject.meshAdolescenten
dc.titleSystematic review of dengue vaccine efficacyen
dc.typeArticle
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