Impact of Early Valve Surgery on Outcome of Staphylococcus aureus Prosthetic Valve Infective Endocarditis: Analysis in the International Collaboration of Endocarditis–Prospective Cohort Study

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dc.contributor.authorChirouze, Catherine
dc.contributor.authorAlla, François
dc.contributor.authorFowler, Vance G.
dc.contributor.authorSexton, Daniel J.
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorChu, Vivian H.
dc.contributor.authorWang, Andrew
dc.contributor.authorErpelding, Marie-Line
dc.contributor.authorDurante-Mangoni, Emanuele
dc.contributor.authorFernández-Hidalgo, Nuria
dc.contributor.authorGiannitsioti, Efthymia
dc.contributor.authorHannan, Margaret M.
dc.contributor.authorLejko-Zupanc, Tatjana
dc.contributor.authorMiró, José M.
dc.contributor.authorMuñoz, Patricia
dc.contributor.authorMurdoch, David R.
dc.contributor.authorTattevin, Pierre
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorHoen, Bruno
dc.date.accessioned2022-08-10T14:22:01Z
dc.date.available2022-08-10T14:22:01Z
dc.date.issued2015
dc.description.abstractBackground: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods: Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results: EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions: In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE. Keywords: 1-year mortality; endocarditis; prosthetic valve; surgery.
dc.identifier.citationChirouze C, Alla F, Fowler V, Sexton DJ, Corey GR, Chu VH et al. Impact of Early Valve Surgery on Outcome of Staphylococcus aureus Prosthetic Valve Infective Endocarditis: Analysis in the International Collaboration of Endocarditis–Prospective Cohort Study. Clin Infect Dis. 2015;60(5):741-749.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/78
dc.language.isoen
dc.publisherInfectious Diseases Society of America
dc.subject.meshTreatment Outcomeen
dc.subject.meshSurvival Analysisen
dc.subject.meshStaphylococcus aureus / isolation & purificationen
dc.subject.meshStaphylococcal Infections / surgeryen
dc.subject.meshStaphylococcal Infections / pathologyen
dc.subject.meshStaphylococcal Infections / mortalityen
dc.subject.meshStaphylococcal Infections / microbiologyen
dc.subject.meshProsthesis-Related Infections / surgeryen
dc.subject.meshProsthesis-Related Infections / pathologyen
dc.subject.meshProsthesis-Related Infections / mortalityen
dc.subject.meshProsthesis-Related Infections / microbiologyen
dc.subject.meshProspective Studiesen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshInternational Cooperationen
dc.subject.meshHumansen
dc.subject.meshHeart Valves / surgeryen
dc.subject.meshFemaleen
dc.subject.meshEndocarditis / surgeryen
dc.subject.meshEndocarditis / pathologyen
dc.subject.meshEndocarditis / mortalityen
dc.subject.meshEndocarditis / microbiologyen
dc.subject.meshCohort Studiesen
dc.subject.meshAgeden
dc.subject.meshAdulten
dc.titleImpact of Early Valve Surgery on Outcome of Staphylococcus aureus Prosthetic Valve Infective Endocarditis: Analysis in the International Collaboration of Endocarditis–Prospective Cohort Study
dc.typeArticle
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