A Systematic Review and a Meta-Analysis of the Yellow Fever Vaccine in the Elderly Population
A Systematic Review and a Meta-Analysis of the Yellow Fever Vaccine in the Elderly Population
| dc.contributor.author | Abreu, Ariane de Jesus Lopes de | |
| dc.contributor.author | Cavalcante, João Roberto | |
| dc.contributor.author | Lagos, Letícia Wigg de Araújo | |
| dc.contributor.author | Caetano, Rosângela | |
| dc.contributor.author | Braga, José Ueleres | |
| dc.date.accessioned | 2024-12-05T17:15:47Z | |
| dc.date.available | 2024-12-05T17:15:47Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | We conducted a systematic review and a meta-analysis to assess the risk of serious adverse events in the elderly after yellow fever vaccination compared to the non-elderly population. We searched multiple databases and grey literature, and we selected research without language and publication date restrictions. Studies were analyzed in a descriptive way and meta-analyzed and expressed in terms of prevalence ratio and risk ratio with a 95% confidence interval, depending on the degree of heterogeneity found. A total of 18 studies were included and 11 were meta-analyzed. The results obtained through the meta-analysis showed a risk of serious adverse events after yellow fever vaccination three times higher for the elderly when compared to the non-elderly popula- tion and five times higher for persons > 70 years. In relation to adverse event types, viscerotropic disease associated with the yellow fever vaccine had a risk that was six times higher when com- pared to the population < 60 years. The evidence found supports that the vaccine indication in individuals > 60 years of age should be based on a careful analysis of individual benefit-risk assess- ments. The results found suggest a higher risk of events for individuals > 70 years, especially for viscerotropic and neurotropic disease associated with YFV contraindicating the use of the YFV in this age group. | |
| dc.identifier.citation | de Abreu AJL, Cavalcante JR, de Araújo Lagos LW, Caetano R, Braga JU. A Systematic Review and a Meta-Analysis of the Yellow Fever Vaccine in the Elderly Population. Vaccines (Basel). 2022 Apr 30;10(5):711. doi: 10.3390/vaccines10050711. | |
| dc.identifier.other | 10.3390/vaccines10050711 Full text linksCite | |
| dc.identifier.uri | https://dspace.inc.saude.gov.br/handle/123456789/664 | |
| dc.language.iso | en | |
| dc.publisher | Vaccines | |
| dc.subject | yellow fever vaccine | en |
| dc.subject | adverse events | en |
| dc.subject | systematic review | en |
| dc.subject | aged. | en |
| dc.title | A Systematic Review and a Meta-Analysis of the Yellow Fever Vaccine in the Elderly Population | |
| dc.type | Article |