Impact and economic analysis of human T-cell lymphotropic virus type 1 (HTLV-1)-targeted antenatal screening, England and Wales, 2021
Impact and economic analysis of human T-cell lymphotropic virus type 1 (HTLV-1)-targeted antenatal screening, England and Wales, 2021
Data
2024
Autores
Rosadas, Carolina
Costa, Milene
Senna, Kátia
Santos, Marisa
Taylor, Graham P
Journal Title
Journal ISSN
Volume Title
Publisher
Euro Surveillance
Resumo
Background: Human T-cell lymphotropic virus type 1
(HTLV-1) is a neglected virus that can cause severe dis-
ease and be transmitted from mother to child through
breastfeeding. Avoidance of breastfeeding prevents
80% of vertical transmission. The United Kingdom
(UK) is currently assessing whether HTLV-1-targeted
antenatal screening should be implemented. Aim: We
aimed to assess the impact and cost-effectiveness of
a targeted programme to prevent HTLV-1 vertical trans-
mission in England and Wales. Methods: We estimated
the number of pregnant women who have high risk
of HTLV-1 infection based on their or their partner’s
country of birth. With data from 2021, we used a math-
ematical model to assess cost-effectiveness of HTLV-1
antenatal screening. We also estimated the annual
number of infant infections and the number that
could be prevented with screening and intervention.
Results: We estimate that ca 99,000 pregnant women
in England and Wales have high risk of HTLV-1 infec-
tion. In the absence of screening, 74 (range: 25–211)
HTLV-1 infections in infants would be expected to occur
every year in England and Wales. Implementation of
targeted screening would prevent 58 (range: 19–164)
infant infections annually. The intervention is effec-
tive (incremental 0.00333 quality-adjusted life years
(QALY)) and cost-saving (GBP −57.56 (EUR −66.85)).
Conclusion: Our findings support implementation of
HTLV-1 targeted antenatal screening to reduce vertical
transmission from mothers to infants in the UK.
Description
Palavras-chave
HTLV, antenatal screening, cost-utility analysis, economic analysis, maternal health, mother-to-child transmission, prevention, vertical transmission.
Citação
Rosadas C, Costa M, Senna K, Santos M, Taylor GP. Impact and economic analysis of human T-cell lymphotropic virus type 1 (HTLV-1)-targeted antenatal screening, England and Wales, 2021. Euro Surveill. 2024 May;29(22):2300537. doi: 10.2807/1560-7917.ES.2024.29.22.2300537.