Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
Data
2024
Autores
Innocenzi, Adriana
Rangel, Isabela
Póvoa‐Corrêa, Mariana
Parente, Daniella Braz
Perez, Renata
Rodrigues, Rosana Souza
Fukuyama, Lúcia Tomoko
Barroso, Julia Machado
Oliveira Neto, Jaime Araújo
Sousa, Andréa Silvestre de
Journal Title
Journal ISSN
Volume Title
Publisher
Pediatric Cardiology
Resumo
The abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results in hepatic
venous congestion and Fontan-associated liver disease. Combined assessment of cardiac and liver fbrosis and cardiac
remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fbrosis
and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients
and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann–Whitney, Fisher exact test, and
Spearman’s correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs
and liver stifness. The mean native cardiac T1 value (p=0.018), cardiac ECV (p<0.001), liver native T1 (p<0.001), liver
ECV (p<0.001), and liver stifness (p<0.001) were higher in patients than controls. The indexed end-diastolic volume
(EDVi) correlated with the myocardial ECV (r=0.356; p=0.033), native liver T1 (r=0.571; p<0.001), and with liver stif-
ness (r=0.391; p=0.015). In addition, liver stifness correlated with liver ECV (r=0.361; p=0.031) and native liver T1
(r=0.458; p=0.004). An association between cardiac remodeling and cardiac and liver fbrosis were found in this population.
The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies
and to prevent the need for combined liver and heart transplantation.
Description
Palavras-chave
Fontan, Fibrosis, T1 mapping, Extracellular volume, MRI, Fontan-associated liver disease.
Citação
Innocenzi A, Rangel I, Póvoa-Corrêa M, Parente DB, Perez R, Rodrigues RS, Fukuyama LT, Barroso JM, Oliveira Neto JA, Silvestre de Sousa A, Luiz RR, Barbosa RCP, Camargo GC, Moll-Bernardes R. Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation. Pediatr Cardiol. 2024 May 21. doi: 10.1007/s00246-024-03522-9.