Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation

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dc.contributor.authorInnocenzi, Adriana
dc.contributor.authorRangel, Isabela
dc.contributor.authorPóvoa‐Corrêa, Mariana
dc.contributor.authorParente, Daniella Braz
dc.contributor.authorPerez, Renata
dc.contributor.authorRodrigues, Rosana Souza
dc.contributor.authorFukuyama, Lúcia Tomoko
dc.contributor.authorBarroso, Julia Machado
dc.contributor.authorOliveira Neto, Jaime Araújo
dc.contributor.authorSousa, Andréa Silvestre de
dc.contributor.authorLuiz, Ronir Raggio
dc.contributor.authorBarbosa, Rosa Célia Pimentel
dc.contributor.authorCamargo, Gabriel Cordeiro
dc.contributor.authorMoll‐Bernardes, Renata
dc.date.accessioned2025-02-04T13:54:08Z
dc.date.available2025-02-04T13:54:08Z
dc.date.issued2024
dc.description.abstractThe abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results in hepatic venous congestion and Fontan-associated liver disease. Combined assessment of cardiac and liver fbrosis and cardiac remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fbrosis and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann–Whitney, Fisher exact test, and Spearman’s correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs and liver stifness. The mean native cardiac T1 value (p=0.018), cardiac ECV (p<0.001), liver native T1 (p<0.001), liver ECV (p<0.001), and liver stifness (p<0.001) were higher in patients than controls. The indexed end-diastolic volume (EDVi) correlated with the myocardial ECV (r=0.356; p=0.033), native liver T1 (r=0.571; p<0.001), and with liver stif- ness (r=0.391; p=0.015). In addition, liver stifness correlated with liver ECV (r=0.361; p=0.031) and native liver T1 (r=0.458; p=0.004). An association between cardiac remodeling and cardiac and liver fbrosis were found in this population. The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies and to prevent the need for combined liver and heart transplantation.
dc.identifier.citationInnocenzi A, Rangel I, Póvoa-Corrêa M, Parente DB, Perez R, Rodrigues RS, Fukuyama LT, Barroso JM, Oliveira Neto JA, Silvestre de Sousa A, Luiz RR, Barbosa RCP, Camargo GC, Moll-Bernardes R. Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation. Pediatr Cardiol. 2024 May 21. doi: 10.1007/s00246-024-03522-9.
dc.identifier.otherDOI: 10.1007/s00246-024-03522-9
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/786
dc.language.isoen
dc.publisherPediatric Cardiology
dc.subjectFontanen
dc.subjectFibrosisen
dc.subjectT1 mappingen
dc.subjectExtracellular volumeen
dc.subjectMRIen
dc.subjectFontan-associated liver disease.en
dc.titleCardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
dc.typeArticle
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