Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
Data
2022
Autores
Kocarnik, JM
Compton, K
Dean, FE
Fu, W
Gaw, BL
Zimmermann, IR
Journal Title
Journal ISSN
Volume Title
Publisher
JAMA Oncology
Resumo
IMPORTANCE The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD
2019) provided systematic estimates of incidence, morbidity, and mortality to inform local
and international efforts toward reducing cancer burden.
OBJECTIVE To estimate cancer burden and trends globally for 204 countries and territories
and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.
EVIDENCE REVIEW The GBD 2019 estimation methods were used to describe cancer
incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life
years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of
the SDI, a composite measure of educational attainment, income per capita, and total fertility
rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).
FINDINGS In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new
cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95%
UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million)
DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%)
increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95%
UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD
2019 study, cancer was second only to cardiovascular diseases for the number of deaths,
years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The
proportion of years lived with disability that contributed to DALYs increased with SDI, ranging
from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile.
While the high SDI quintile had the highest number of new cases in 2019, the middle SDI
quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest
percentage increase in the numbers of cases and deaths occurred in the low and low-middle
SDI quintiles.
CONCLUSIONS AND RELEVANCE The results of this systematic analysis suggest that the global
burden of cancer is substantial and growing, with burden differing by SDI. These results
provide comprehensive and comparable estimates that can potentially inform efforts toward
equitable cancer control around the world.
Description
Palavras-chave
Disability-Adjusted Life Years, Global Burden of Disease*, Global Health, Humans, Incidence, Neoplasms* / epidemiology, Prevalence, Quality-Adjusted Life Years, Risk Factors
Citação
Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, Zimmermann IR et al. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2022 Mar 1;8(3):420-444. doi: 10.1001/jamaoncol.2021.6987.