Associations between endothelial progenitor cells, clinical characteristics and coronary restenosis in patients undergoing percutaneous coronary artery intervention
Associations between endothelial progenitor cells, clinical characteristics and coronary restenosis in patients undergoing percutaneous coronary artery intervention
Data
2018
Autores
Montenegro, Fernando S.
Correia, Marcelo
Muccillo, Fabiana
Silva, Christina G. Souza e
De Lorenzo, Andrea
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Research Notes
Resumo
Objective: Endothelial progenitor cells (EPCs) are produced in the bone marrow and mobilized to the peripheral
blood playing a key role in endothelial repair. The objective of this study was to evaluate circulating EPC before and
after percutaneous coronary intervention (PCI) with stent implantation and their associations with coronary restenosis
and adverse cardiovascular events. Venous blood was obtained before and the day after PCI. Quantifcation of total
white blood count and identifcation of EPCs (CD45−CD34+CD31+CD133/2+CD309+) through immunophenotyping
by fow cytometry was performed. The primary outcome was either restenosis detected by new coronary angiog-
raphy or angina with myocardial ischemia at the territory of the stented coronary artery. Secondary outcomes were
angina without demonstrable myocardial ischemia, acute coronary syndrome or all-cause death.
Results: 37 patients were followed for 1 year. The median EPC count before PCI was 320 cells/mcl and after PCI
286 cells/mcl. A decrease of EPC count was found in 65% of the patients, while 35% displayed an increase. Pri-
mary outcomes occurred in 10.8% and the secondary in 37.8% of the patients. Despite a higher level of EPC before
(402 cell/mcl) and after PCI (383 cell/mcl) in patients with the secondary outcomes, there was no signifcant associa-
tion between EPC and cardiovascular events.
Description
Palavras-chave
Endothelial progenitor cells, Coronary artery disease, Angioplasty, Restenosis, Angina pectoris, Acute coronary syndrome, Percutaneous coronary
Citação
Montenegro FS, Correia M, Muccillo F, Souza E Silva CG, De Lorenzo A. Associations between endothelial progenitor cells, clinical characteristics and coronary restenosis in patients undergoing percutaneous coronary artery intervention. BMC Res Notes. 2018 May 8;11(1):278. doi: 10.1186/s13104-018-3401-y.