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    Accuracy of positron emission tomography and positron emission tomography-CT in the detection of differentiated thyroid cancer recurrence with negative 131I whole-body scan results: A meta-analysis
    (Head & Neck, 2016) Caetano, Rosângela; Bastos, Claudia Regina Garcia; Oliveira, Ione Ayala Gualandi de; Silva, Rondineli Mendes da; Fortes, Clarisse Pereira Dias Drumond; Pepe, Vera Lucia Edais; Reis, Lenice Gnocchi; Braga, Jose Ueleres
    Background. The purpose of this review was to present a meta-analysis aimed to evaluate the accuracy of positron emission tomography (PET) and PET-CT for detecting recurrence of differentiated thyroid carcinoma (DTC) not identified by 131I whole-body scintigraphy. Methods. MEDLINE, EMBASE, LILACS, and Cochrane databases were searched for studies published between January 1985 and March 2012. Systematic methods were used to select and evaluate the quality of studies. Pooled sensitivity and specificity for conventional PET and PET- CT was estimated using random effects model. Results. Twenty studies were included in the systematic review; the data of 18 studies were used in the meta-analysis. The combined sensitivity and specificity for conventional PET were both found to be 84%; for PET- CT, they were 93% and 81%, respectively. The overall accuracies were 91% and 93%, respectively. Conclusion. 18Fluorodeoxyglucose (FDG)-PET and PET-CT are highly accurate diagnostics tools for DTC recurrence in patients who present a negative whole-body scintigraphy and could impact the clinical and ther- apeutic management of DTC. VC 2015 Wiley Periodicals, Inc. Head Neck 38: 316–327, 2016.