Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics

Página do item simplificado
dc.contributor.authorBraga, José Ueleres
dc.contributor.authorBressan, Clarisse
dc.contributor.authorDalvi, Ana Paula Razal
dc.contributor.authorCalvet, Guilherme Amaral
dc.contributor.authorDaumas, Regina Paiva
dc.contributor.authorRodrigues, Nadia
dc.contributor.authorWakimoto, Mayumi
dc.contributor.authorNogueira, Rita Maria Ribeiro
dc.contributor.authorNielsen-Saines, Karin
dc.contributor.authorBrito, Carlos
dc.contributor.authorFilippis, Ana Maria Bispo de
dc.contributor.authorBrasil, Patrícia
dc.date.accessioned2024-11-14T15:01:05Z
dc.date.available2024-11-14T15:01:05Z
dc.date.issued2017
dc.description.abstractBackground Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barre ́ syn- drome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molec- ular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and new- borns. In this context, an accurate definition of a suspected Zika case is crucial in order for the surveillance system to gauge the magnitude of an epidemic. Methodology We evaluated the accuracy of various Zika case definitions in a scenario where Dengue and Chikungunya viruses co-circulate. Signs and symptoms that best discriminated PCR con- firmed Zika from other laboratory confirmed febrile or exanthematic diseases were identified to propose and test predictive models for Zika infection based on these clinical features. Results and discussion Our derived score prediction model had the best performance because it demonstrated the highest sensitivity and specificity, 866% and 783%, respectively. This Zika case definition also had the highest values for auROC (0903) and R2 (0417), and the lowest Brier score 0096. Conclusions In areas where multiple arboviruses circulate, the presence of rash with pruritus or conjuncti- val hyperemia, without any other general clinical manifestations such as fever, petechia or anorexia is the best Zika case definition.
dc.identifier.citationBraga JU, Bressan C, Dalvi APR, Calvet GA, Daumas RP, Rodrigues N, et al. (2017). Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics. PLoS ONE 12(6): e0179725. Doi: 10.1371/journal.pone.0179725
dc.identifier.otherDOI: 10.1371/journal.pone.0179725
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/612
dc.language.isoen
dc.publisherPLOS One
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBrazil / epidemiologyen
dc.subjectChikungunya Fever / diagnosisen
dc.subjectChikungunya Fever / epidemiology*en
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectCross-Sectional Studiesen
dc.subjectDengue / diagnosisen
dc.subjectDengue / epidemiology*en
dc.subjectDiagnosis, Differentialen
dc.subjectEpidemics*en
dc.subjectEpidemiological Monitoringen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectInfectious Disease Transmission, Verticalen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectModels, Statisticalen
dc.subjectPredictive Value of Testsen
dc.subjectPregnancyen
dc.subjectYoung Adulten
dc.subjectZika Virus Infection / diagnosis*en
dc.subjectZika Virus Infection / epidemiology*en
dc.subjectZika Virus Infection / transmissionen
dc.titleAccuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics
dc.typeArticle
Arquivos
Original bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.alt
Nome:
Braga JU et al_PLOS One.pdf
Tamanho:
97.24 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
License bundle
Agora exibindo 1 - 1 de 1
thumbnail.default.placeholder
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed to upon submission
Descrição:
Baixar
Coleções
Produção Docente