A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe chagas cardiomyopathy: a pilot single-arm clinical trial

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dc.contributor.authorRodrigues Junior, Luiz Fernando
dc.contributor.authorMendes, Fernanda de Souza Nogueira Sardinha
dc.contributor.authorPinto, Vivian Liane Mattos
dc.contributor.authorSilva, Paula Simplicio da
dc.contributor.authorSilva, Gilberto Marcelo Sperandio da
dc.contributor.authorPinheiro, Roberta Olmo
dc.contributor.authorSousa, Andréa Silvestre de
dc.contributor.authorMediano, Mauro Felippe Felix
dc.date.accessioned2022-09-12T12:24:01Z
dc.date.available2022-09-12T12:24:01Z
dc.date.issued2020
dc.description.abstractBackground: Cardiac rehabilitation exerts anti‑ inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro‑ inflammatory imbalance. Materials and Methods: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin‑ 1 beta (IL‑ 1β ), IL‑ 8, IL‑ 10, interferon gamma (IF‑ γ ), tumor necrosis factor alpha (TNF‑ α ), and monocyte chemoattractant protein‑ 1 (MCP‑ 1) serum levels were measured using enzyme‑ linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one‑ way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons. Results: Levels of pro‑ inflammatory (TNF‑ α , IL‑ 1β , IL‑ 8, IF‑ γ , and (MCP‑ 1) and anti‑ inflammatory (IL‑ 10) cytokines did not vary significantly during the observation period. Conclusion: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro‑ inflammatory cytokines in this disease characterized by a continuous state of inflammation.en
dc.identifier.citationRodrigues Junior LF, Mendes FSNS, Pinto VLM, Silva PS, Silva GMS, Pinheiro RO, Sousa AS, Mediano MFF. A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial (Short Communication). J Res Med Sci. 2020; 25(2):18.
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/232
dc.language.isoen
dc.publisherJournal of Research in Medical Sciences
dc.subjectCardiac rehabilitationen
dc.subjectChagas cardiomyopathyen
dc.subjectCytokinesen
dc.subjectHeart failureen
dc.titleA cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe chagas cardiomyopathy: a pilot single-arm clinical trialen
dc.typeArticleen
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