Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers

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dc.contributor.authorPeçanha, Daniela
dc.contributor.authorHuguenin, Grazielle Vilas Bôas
dc.contributor.authorLorenzo, Andrea De
dc.contributor.authorTibirica, Eduardo
dc.date.accessioned2022-09-14T14:16:16Z
dc.date.available2022-09-14T14:16:16Z
dc.date.issued2020
dc.description.abstractObjective This study evaluated the acute effect of a high-carbohydrate snack (HCS) on systemic microvascular function of healthy, young volunteers, using laser speckle contrast imaging (LSCI). Methods Cutaneous microvascular blood flow was assessed in the forearm with LSCI coupled to iontophoresis of acetylcholine, using increasing anodal currents, before and after (25 min) the ingestion of a HCS or water (control). Twenty volunteers (10 male) received a single HCS (70 g of carbohydrates) in the fasting state in the morning. Results The area under the curve (AUC) of acetylcholine-induced microvascular vasodilation increased from 17,847 ± 4539 to 20,315 ± 7168 arbitrary perfusion units/s (P = 0.03) after ingestion of a HCS, but was unchanged after the ingestion of water (P = 0.22). Conclusion A single snack consisting on an acute oral load of carbohydrates induced a significant increase of endothelium-dependent microvascular vasodilation in healthy, young subjects.en
dc.identifier.citationPeçanha D, Huguenin GVB, Lorenzo A, Tibiriça E. Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers. Microvascular Research. 2020;129:103962.
dc.identifier.doiDOI: 10.1016/j.mvr.2019.103962
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/274
dc.language.isoen
dc.publisherMicrovascular Research
dc.subjectLaser-based methodsen
dc.subjectMicrovascular endothelial functionen
dc.subjectHigh carbohydrate snacken
dc.subjectLaser speckle contrast imagingen
dc.subject.meshYoung Adulten
dc.subject.meshVasodilationen
dc.subject.meshTime Factorsen
dc.subject.meshSnacksen
dc.subject.meshSkin / blood supplyen
dc.subject.meshRegional Blood Flowen
dc.subject.meshMicrovessels / physiologyen
dc.subject.meshMicrocirculationen
dc.subject.meshMaleen
dc.subject.meshHumansen
dc.subject.meshHealthy Volunteersen
dc.subject.meshForearmen
dc.subject.meshFemaleen
dc.subject.meshEndothelium, Vascular / physiologyen
dc.subject.meshDietary Carbohydrates / administration & dosageen
dc.subject.meshBlood Flow Velocityen
dc.subject.meshAdulten
dc.subject.meshAdolescenten
dc.titleIncreased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteersen
dc.typeArticle
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