Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers
Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers
Data
2020
Autores
Peçanha, Daniela
Huguenin, Grazielle Vilas Bôas
Lorenzo, Andrea De
Tibirica, Eduardo
Journal Title
Journal ISSN
Volume Title
Publisher
Microvascular Research
Resumo
Objective This study evaluated the acute effect of a high-carbohydrate snack (HCS) on systemic microvascular function of healthy, young volunteers, using laser speckle contrast imaging (LSCI). Methods Cutaneous microvascular blood flow was assessed in the forearm with LSCI coupled to iontophoresis of acetylcholine, using increasing anodal currents, before and after (25 min) the ingestion of a HCS or water (control). Twenty volunteers (10 male) received a single HCS (70 g of carbohydrates) in the fasting state in the morning. Results The area under the curve (AUC) of acetylcholine-induced microvascular vasodilation increased from 17,847 ± 4539 to 20,315 ± 7168 arbitrary perfusion units/s (P = 0.03) after ingestion of a HCS, but was unchanged after the ingestion of water (P = 0.22). Conclusion A single snack consisting on an acute oral load of carbohydrates induced a significant increase of endothelium-dependent microvascular vasodilation in healthy, young subjects.
Description
Palavras-chave
Laser-based methods, Microvascular endothelial function, High carbohydrate snack, Laser speckle contrast imaging
Citação
Peçanha D, Huguenin GVB, Lorenzo A, Tibiriça E. Increased systemic endothelial-dependent microvascular reactivity after ingestion of a high-carbohydrate snack in young, healthy volunteers. Microvascular Research. 2020;129:103962.