Systemic microvascular dysfunction in COVID-19
Systemic microvascular dysfunction in COVID-19
Data
2020
Autores
Sabioni, Leticia R
Tibirica, Eduardo
Lamas, Cristiane C.
Amorim, Guilherme D.
Lorenzo, Andrea De
Journal Title
Journal ISSN
Volume Title
Publisher
American Journal of Cardiovascular Disease
Resumo
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while having lung injury as its most prominent feature, has been increasingly shown to affect endothelial cell function and the microvasculature. In this report, a woman with COVID-19, cardiac valve disease and spherocytosis was assessed with laser Doppler perfusion monitoring. Systemic microvascular reactivity was impaired during a worsening phase of COVID-19, but improved after clinical recovery; microcirculatory dysfunction paralleled systemic inflammation and pulmonary involvement. The assessment of systemic microcirculatory function may therefore provide insights on COVID-19 pathophysiology.
Description
Palavras-chave
COVID-19, Laser Doppler perfusion imaging, Endothelial dysfunction, Microvascular reactivity, Cardiac valve disease
Citação
Sabioni LR, Tibirica E, Lamas CC, Amorim GD, Lorenzo AD. Systemic microvascular dysfunction in COVID-19. Am J Cardiovasc Dis. 2020; 10(4): 386–391.