The Role of Strain in the Prognosis of Transthyretin Amyloidosis
The Role of Strain in the Prognosis of Transthyretin Amyloidosis
Data
2024
Autores
Silva, Ana Karolina Bento Bento da
Cavalcanti, Leonardo Torreão Bezerra
Barberato, Silvio Henrique
Felix, Alex dos Santos
Melo, Marcelo Dantas Tavares de
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Cardiovascular Sciences
Resumo
Transthyretin amyloidosis (TTRA) is a systemic infiltrative disease where cardiac involvement is paramount for prognosis. The strain technique plays a crucial role in non-invasive cardiac screening for this condition. Research on the prognostic utility of cardiac deformation in TTRA indicates the significance of right ventricular (RV) free wall strain, global longitudinal strain (GLS), left and right atrium reservoir strain, in descending order of publication, respectively. The GLS has emerged as a promising tool for therapeutic monitoring. Analyzing myocardial deformation is vital due to its incremental value over other clinical, laboratory, and imaging parameters. However, caution is warranted due to limited data on its prognostic and therapeutic monitoring use in TTRA. Despite the strong rationale for employing myocardial deformation in patient stratification, further robust studies are necessary to establish it as a new prognostic marker in TTRA.
Description
Palavras-chave
Echocardiography, Cardiomyopathies, Heart Failure.
Citação
Silva AKBB, Cavalcanti LTB, Barberato SH, Felix AS, Melo MDT. The Role of Strain in the Prognosis of Transthyretin Amyloidosis. Int J Cardiovasc Sci 2024;37:e20240082. doi: 10.36660/ijcs.20240082.