Early Palliative Care for Improving Quality of Life and Survival in Patients with Advanced Cancer: A Systematic Review and Meta-analysis
Early Palliative Care for Improving Quality of Life and Survival in Patients with Advanced Cancer: A Systematic Review and Meta-analysis
Data
2018
Autores
Zanghelini, Fernando
Zimmermann, Ivan Ricardo
Andrade, Cesar Augusto Souza de
Wu, Olivia
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Palliative Care & Medicine
Resumo
Objective: The main goal was to evaluate the effectiveness of early palliative care in patients with advanced
cancer.
Methods: The search in the MEDLINE/PubMed, CRD, Cochrane Library, CINAHL, EMBASE, Google Scholar,
ICTRP and ClinicalTrials.gov databases was conducted in June 2017. Two reviewers independently screened titles
and abstracts with consensus agreement. We undertook quality assessment according to GRADE criteria.
Randomized Controlled Trials (RCT) that assessed the effectiveness of EPC in adult patients with a diagnosis-
advanced cancer were included. The quantitative evidence was summarized in a meta-analysis using random effect
models.
Results: The selection phase retrieved 14,026 records, 7 papers were included in the meta-analysis. The
standardized mean difference the outcomes assessed were: improvement quality of life (0.17 higher; 95% CI; 0.05,
0.29) after 3 months, (0.42 higher; 95% CI; 0.21, 0.63) after 6 months, and (0.16 higher; 95% CI; -0.20, 0.53) after
12 months; improvement of symptom intensity (-0.13 lower; 95% CI; -0.26, 0.00) after 3 months, (-0.27 lower; 95%
CI; -0.53, -0.01) after 6 months, and (-0.39 lower; 95% CI; -0.76, -0.03) after 12 months; improve depressive mood
(-0.19 lower; 95% CI; - 0.36, -0.01) after 3 months, (-0.21 lower; 95% CI; -0.45, 0.04) after 6 months, and (-0.09
lower; 95% CI; -0.81, 0.63) after 12 months; and survival (OR = 0.71 higher; 95% CI; 0.51, 0.99).
Conclusion: Our findings suggest that EPC effectively improves quality of life and consequently increases the
likelihood of survival of patients with advanced or metastatic cancer. However, due to worsening of the disease
stage over time, a limited effect was observed after 12 months of follow-up.
Description
Palavras-chave
Palliative care, Quality of life, Survival, Neoplasms
Citação
Zanghelini F, Zimmermann IR, Andrade CAS, Wu O (2018) Early Palliative Care for Improving Quality of Life and Survival in Patients with Advanced Cancer: A Systematic Review and Meta-analysis. J Palliat Care Med 8: 343. DOI: 10.4172/2165-7386.1000343.