Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country

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dc.contributor.authorSchtruk, Lígia Beatriz Chaves Espinoso
dc.contributor.authorGuimarães, Tereza Cristina Fellipe
dc.contributor.authorPôrto, Luis Cristóvão
dc.contributor.authorKuschnir, Maria Cristina Caetano
dc.contributor.authorColafranceschi, Alexandre Siciliano
dc.contributor.authorSilva Filho, Paulo Moreira da
dc.contributor.authorLorenzo, Andrea De
dc.date.accessioned2022-09-13T13:59:16Z
dc.date.available2022-09-13T13:59:16Z
dc.date.issued2016
dc.description.abstractThe notable evolution of heart transplant (HTX) has paralleled the capacity of diagnosing rejection and, consequently, initiating timely treatment. Acute cellular rejection, diagnosed by endomyocardial biopsy, is the most frequent in the first 6 months after HTX. HLA matching is not routinely performed in HTX due to the absence of consensus regarding its usefulness. However, the use of HLA typing might be underscored if it could predict an increased risk of rejection. Therefore, the aim of this study was to evaluate, at a public cardiology center in Brazil, the association between HLA mismatches and the incidence of acute cellular rejection in the first 6 months after HTX. Data were obtained from hospital records and from the National Transplant System. Overall, there was no association between the number of HLA mismatches and the frequency of acute cellular rejection, but there was a tendency toward a higher incidence of rejection with HLA-DR incompatibility.en
dc.identifier.citationSchtruk LBCE, Guimarães TCF, Pôrto LC, Kuschnir MCC, Colafranceschi AS, Silva Filho PM, Lorenzo AD. Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country. Clin Transplant. 2016;30(9): 1178-1181.
dc.identifier.doiDOI: 10.1111/ctr.12801
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/255
dc.language.isoen
dc.publisherClinical Transplantation
dc.subjectCardiac transplantationen
dc.subjectHLAen
dc.subjectHLA incompatibilityen
dc.subjectRejectionen
dc.subject.meshRetrospective Studies
dc.subject.meshMiddle Aged
dc.subject.meshMale
dc.subject.meshIncidence
dc.subject.meshHumans
dc.subject.meshHistocompatibility Testing
dc.subject.meshHistocompatibility / immunology
dc.subject.meshHeart Transplantation / adverse effects
dc.subject.meshGraft Survival
dc.subject.meshGraft Rejection / immunology
dc.subject.meshGraft Rejection / epidemiology
dc.subject.meshGraft Rejection / diagnosis
dc.subject.meshFemale
dc.subject.meshDeveloping Countries
dc.subject.meshBrazil / epidemiology
dc.subject.meshBiopsy
dc.subject.meshAcute Disease
dc.titleAcute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country
dc.typeArticle
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