Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country
Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country
Data
2016
Autores
Schtruk, Lígia Beatriz Chaves Espinoso
Guimarães, Tereza Cristina Fellipe
Pôrto, Luis Cristóvão
Kuschnir, Maria Cristina Caetano
Colafranceschi, Alexandre Siciliano
Silva Filho, Paulo Moreira da
Lorenzo, Andrea De
Journal Title
Journal ISSN
Volume Title
Publisher
Clinical Transplantation
Resumo
The notable evolution of heart transplant (HTX) has paralleled the capacity of diagnosing rejection and, consequently, initiating timely treatment. Acute cellular rejection, diagnosed by endomyocardial biopsy, is the most frequent in the first 6 months after HTX. HLA matching is not routinely performed in HTX due to the absence of consensus regarding its usefulness. However, the use of HLA typing might be underscored if it could predict an increased risk of rejection. Therefore, the aim of this study was to evaluate, at a public cardiology center in Brazil, the association between HLA mismatches and the incidence of acute cellular rejection in the first 6 months after HTX. Data were obtained from hospital records and from the National Transplant System. Overall, there was no association between the number of HLA mismatches and the frequency of acute cellular rejection, but there was a tendency toward a higher incidence of rejection with HLA-DR incompatibility.
Description
Palavras-chave
Cardiac transplantation, HLA, HLA incompatibility, Rejection
Citação
Schtruk LBCE, Guimarães TCF, Pôrto LC, Kuschnir MCC, Colafranceschi AS, Silva Filho PM, Lorenzo AD. Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country. Clin Transplant. 2016;30(9): 1178-1181.