Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity
Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity
| dc.contributor.author | Silva, Patrício Braz da | |
| dc.contributor.author | Diniz, Clara Pinto | |
| dc.contributor.author | Mediano, Mauro Felippe Felix | |
| dc.contributor.author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| dc.contributor.author | Hasslocher-Moreno, Alejandro Marcel | |
| dc.contributor.author | Reis, Luis Felipe Fonseca | |
| dc.contributor.author | Reis, Michel Silva | |
| dc.date.accessioned | 2025-11-28T16:51:52Z | |
| dc.date.available | 2025-11-28T16:51:52Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Background:With theevolutionof chronicChagas cardiomyopathy (CC) and theprogression towardsheart failure(HF),patientsmayshowadeclineininspiratorymusclestrength, lungfunction,andfunctionalcapacity. Objective:WecomparedrespiratoryfunctionandsubmaximalfunctionalcapacityinpatientswithCCwithversus withoutHF. Methods:Thisobservational,cross-sectional studywascarriedoutwithCCpatientsdividedintoCCG,agroup withoutHF(n=28),andHFG,agroupwithHF(n=27).Spirometry(percentpredictedforcedvitalcapacity (ppFVC),forcedexpiratoryvolumeinonesecondofFVC(ppFEV1),forcedexpiratoryflowbetween25%and75 %ofFVC(ppFEF25–75%),andmaximumvoluntaryventilation(ppMVV))andsubmaximal functionalcapacity (six-minutesteptest:6MST)wereevaluated.Mann-Whitney(comparisonofpulmonaryfunctionandfunctional capacitybetweengroups)andlinearregression(associationbetweenthepresenceofHFandothervariables) wereperformed. Results:Weincluded55participants,withmedianageof67years(56.25–71.75)and54.55%males.Dyslipidemiawasthemostrecurrentcomorbidity(49.09%).HFGpresentedlowerppFVC(P=0.000),ppFEV1(P= 0.011),ppFEF25–75%(P=0.017),andppMVV(P=0.003)thantheCCG.TheppFVC(B=-18.95;P=0.000), ppFEV1(B=-16.29;P=0.021),ppFEF25–75%(B=-19.57;P=0.014),ppMVV(B=-16.59;P=0.003),and 6MST(B=-17.13;P=0.034)werenegativelyassociatedwiththepresenceofHF. Conclusion:Ourdatasuggest that impairedlungfunction, compatiblewitharestrictivepulmonarypattern, is presentamongadultswithCCandHF. | |
| dc.identifier.citation | Silva PB, Diniz CP, Mediano MFF, Mendes FSNS, Hasslocher-Moreno AM, Reis LFF, Reis MS, Saraiva RM, de Holanda MT, Mazzoli-Rocha F, de Sousa AS. Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity. Heart Lung. 2025 Jan-Feb;69:222-228. doi: 10.1016/j.hrtlng.2024.10.009. | |
| dc.identifier.other | DOI: 10.1016/j.hrtlng.2024.10.009 | |
| dc.identifier.uri | https://dspace.inc.saude.gov.br/handle/123456789/1043 | |
| dc.language.iso | en | |
| dc.publisher | Heart & Lung | |
| dc.title | Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity | |
| dc.title.alternative | A insuficiência cardíaca associada à cardiomiopatia chagásica crônica aumenta o risco de comprometimento da função pulmonar e redução da capacidade funcional submáxima | |
| dc.type | Article |