Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity
Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity
Data
2025
Autores
Silva, Patrício Braz da
Diniz, Clara Pinto
Mediano, Mauro Felippe Felix
Mendes, Fernanda de Souza Nogueira Sardinha
Hasslocher-Moreno, Alejandro Marcel
Reis, Luis Felipe Fonseca
Reis, Michel Silva
Journal Title
Journal ISSN
Volume Title
Publisher
Heart & Lung
Resumo
Background:With theevolutionof chronicChagas cardiomyopathy (CC) and theprogression towardsheart failure(HF),patientsmayshowadeclineininspiratorymusclestrength, lungfunction,andfunctionalcapacity. Objective:WecomparedrespiratoryfunctionandsubmaximalfunctionalcapacityinpatientswithCCwithversus withoutHF. Methods:Thisobservational,cross-sectional studywascarriedoutwithCCpatientsdividedintoCCG,agroup withoutHF(n=28),andHFG,agroupwithHF(n=27).Spirometry(percentpredictedforcedvitalcapacity (ppFVC),forcedexpiratoryvolumeinonesecondofFVC(ppFEV1),forcedexpiratoryflowbetween25%and75 %ofFVC(ppFEF25–75%),andmaximumvoluntaryventilation(ppMVV))andsubmaximal functionalcapacity (six-minutesteptest:6MST)wereevaluated.Mann-Whitney(comparisonofpulmonaryfunctionandfunctional capacitybetweengroups)andlinearregression(associationbetweenthepresenceofHFandothervariables) wereperformed. Results:Weincluded55participants,withmedianageof67years(56.25–71.75)and54.55%males.Dyslipidemiawasthemostrecurrentcomorbidity(49.09%).HFGpresentedlowerppFVC(P=0.000),ppFEV1(P= 0.011),ppFEF25–75%(P=0.017),andppMVV(P=0.003)thantheCCG.TheppFVC(B=-18.95;P=0.000), ppFEV1(B=-16.29;P=0.021),ppFEF25–75%(B=-19.57;P=0.014),ppMVV(B=-16.59;P=0.003),and 6MST(B=-17.13;P=0.034)werenegativelyassociatedwiththepresenceofHF. Conclusion:Ourdatasuggest that impairedlungfunction, compatiblewitharestrictivepulmonarypattern, is presentamongadultswithCCandHF.
Description
Palavras-chave
Citação
Silva PB, Diniz CP, Mediano MFF, Mendes FSNS, Hasslocher-Moreno AM, Reis LFF, Reis MS, Saraiva RM, de Holanda MT, Mazzoli-Rocha F, de Sousa AS. Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity. Heart Lung. 2025 Jan-Feb;69:222-228. doi: 10.1016/j.hrtlng.2024.10.009.