Prevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon

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dc.contributor.authorMalacarne, Jocieli
dc.contributor.authorRios, Diana Patricia Giraldo
dc.contributor.authorSilva, Cosme Marcelo Furtado Passos da
dc.contributor.authorBraga, José Ueleres
dc.contributor.authorCamacho, Luiz Antonio Bastos
dc.contributor.authorBasta, Paulo Cesar
dc.date.accessioned2024-11-25T18:01:48Z
dc.date.available2024-11-25T18:01:48Z
dc.date.issued2016
dc.description.abstractIntroduction: Recent studies have shown a high incidence and prevalence of latent tuberculosis infection (LTBI) in indigenous populations around the World. We aimed to estimate the prevalence and annual risk of infection (ARI) as well as to identify factors associated with LTBI in an indigenous population from the Brazilian Amazon. Methods: We conducted a cross-sectional study in 2011. We performed tuberculin skin tests (TSTs), smears and cultures of sputum samples, and chest radiographs for individuals who reported cough for two or more weeks. Associations between LTBI (TST ≥5mm) and socio-demographic, clinical, and epidemiological characteristics were investigated using Poisson regression with robust variance. Prevalence ratio (PR) was used as the measure of association. Results: We examined 263 individuals. The prevalence of LTBI was 40.3%, and the ARI was 2.4%. Age ≥15 years [PR=5.5; 95% confi dence interval (CI): 3.5-8.6], contact with tuberculosis (TB) patients (PR=3.8; 95% CI: 1.2–11.9), previous TB history (PR=1.4; 95% CI: 1.2-1.7), and presence of Bacillus Calmette-Guérin (BCG) scar (PR=1.9, 95% CI: 1.2-2.9) were associated with LTBI. Conclusions: Although some adults may have been infected years prior, the high prevalence of infection and its strong association with age ≥15 years, history of TB, and recent contact with TB patients suggest that the TB transmission risk is high in the study area.
dc.identifier.citationMalacarne J, Rios DP, Silva CM, Braga JU, Camacho LA, Basta PC. Prevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon. Rev Soc Bras Med Trop. 2016 Jul-Aug;49(4):456-64. doi: 10.1590/0037-8682-0220-2016.
dc.identifier.otherDOI: 10.1590/0037-8682-0220-2016
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/622
dc.language.isoen
dc.publisherRevista da Sociedade Brasileira de Medicina Tropical
dc.subjectEpidemiologyen
dc.subjectHealth services indigenousen
dc.subjectMycobacterium tuberculosisen
dc.subjectPublic health surveillanceen
dc.subjectSouth American Indians.en
dc.titlePrevalence and factors associated with latent tuberculosis infection in an indigenous population in the Brazilian Amazon
dc.typeArticle
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