Effectiveness of RHZE-FDC (fixed-dose combination)compared to RH-FDC + Z for tuberculosistreatment in Brazil: a cohort study

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dc.contributor.authorBraga, José Ueleres
dc.contributor.authorTrajman, Anete
dc.date.accessioned2022-08-16T14:28:46Z
dc.date.available2022-08-16T14:28:46Z
dc.date.issued2015
dc.descriptionJosé Ueleres Braga. Instituto Nacional de Cardiologia. Documento produzido em parceria ou por autor vinculado ao INC, mas não consta a informação no documento.
dc.description.abstractBackground:In 2009, Brazil was the sole high-burden country to use three drugs [rifampin (R), isoniazid (H) andpyrazinamide (Z)] as the standard treatment for sensitive tuberculosis, with RH in fixed-dose combination (FDC).In December 2009, the country has adopted the FDC four-drug regimen including ethambutol (E). The rationalewas the expectation to reduce default and resistance rates, by increasing adherence to treatment and avoidingmonotherapy. However, there is no consensus on the superior effectiveness of the RHZE-FDC regimen overRH-FDC + Z. In particular, few studies evaluated its influence on default and smear negativation rates.Methods:We conducted a historic cohort study to assess the effectiveness of RHZE-FDC for the treatment oftuberculosis in Brazil, measured by the rates of treatment default and smear negativation in the second month oftreatment, using secondary data from the national information system known as SINAN-TB.Results:The RHZE-FDC had a protective effect against treatment default compared to RH-FDC + Z, reducing itby 14%. However, it was not possible to show an effect of the RHZE-FDC on the rate of second month smearnegativation. In addition to the regimen, other well-studied individual characteristics, such as older age (over 38 years)and higher education occupation were also protective against default. Conversely, alcoholism increased the probabilityof defaulting. These programmatic findings suggests the benefits of RHZE-FDC over RH-FDC + Z.Conclusion:Our analysis of a cohort database in a high burden country shows that compared to RH-FDC + Z,RHZE-FDC reduces the default rates, independently of other influencing individual or health service factors.en
dc.identifier.citationBraga JU, Trajman A.Effectiveness of RHZE-FDC (fixed-dose combination) compared to RH-FDC + Z for tuberculosis treatment in Brazil: a cohort study. BMC Infect Dis. 2015; 15:81. Doi: 10.1186/s12879-015-0820-4
dc.identifier.otherDOI: 10.1186/s12879-015-0820-4
dc.identifier.urihttps://dspace.inc.saude.gov.br/handle/123456789/100
dc.language.isoen
dc.publisherBMC Infectious Diseases
dc.subjectEffectivenessen
dc.subjectFixed-dose combinationen
dc.subjectTreatmenten
dc.subjectTuberculosisen
dc.subject.meshTuberculosis, Pulmonary / epidemiologyen
dc.subject.meshTuberculosis, Pulmonary / drug therapyen
dc.subject.meshTreatment Outcomeen
dc.subject.meshRifampin / administration & dosageen
dc.subject.meshPyrazinamide / administration & dosageen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshIsoniazid / administration & dosageen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshEthambutol / administration & dosageen
dc.subject.meshDrug Combinationsen
dc.subject.meshCohort Studiesen
dc.subject.meshBrazil / epidemiologyen
dc.subject.meshAntitubercular Agents / administration & dosageen
dc.subject.meshAged, 80 and overen
dc.subject.meshAgeden
dc.subject.meshAdulten
dc.titleEffectiveness of RHZE-FDC (fixed-dose combination)compared to RH-FDC + Z for tuberculosistreatment in Brazil: a cohort studyen
dc.typeArticle
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