Medicamentos e pesquisa translacional: etapas, atores e políticas de saúde no contexto brasileiro
Medicamentos e pesquisa translacional: etapas, atores e políticas de saúde no contexto brasileiro
Data
2019
Autores
Lupatini, Evandro de Oliveira
Barreto, Jorge Otávio Maia
Zimmermann, Ivan Ricardo
Silva, Everton Nunes da
Journal Title
Journal ISSN
Volume Title
Publisher
Saúde Debate
Resumo
A pesquisa translacional surgiu com o objetivo de reduzir o tempo entre a pesquisa
básica e a sua aplicação clínica. Para os medicamentos, esse tempo pode chegar a décadas, o
que denota a necessidade de se avaliarem possíveis barreiras por meio da pesquisa translacio-
nal. Objetivou-se revisar a literatura para identificar as etapas da pesquisa translacional, bem
como os atos normativos, as políticas públicas de saúde e os principais atores no contexto
brasileiro. Para a identificação de modelos da pesquisa translacional, realizou-se revisão com
busca sistemática nas bases PubMed, Embase e Lilacs, sendo selecionadas 23 publicações. Sítios
eletrônicos oficiais foram consultados para o levantamento das políticas e dos atores. Como
resultados, a literatura inicialmente apontava uma etapa (da bancada ao leito), incorporando
recentemente a síntese de pesquisas e a avaliação de impacto na saúde pública como etapas
adicionais. Diversos atores são transversais na pesquisa translacional, como universidades,
instituições de pesquisa e agências de fomento. Observa-se que o Brasil instituiu políticas
importantes nas áreas de assistência farmacêutica, pesquisa, ciência, tecnologia e inovação
em saúde, o que pode potencialmente integrar recursos, atores e esforços visando à aplicação
prática de resultados para melhorar as condições de saúde e de vida da população.
Translational research has come up with the purpose of reducing the time gap between basic research and its clinical application. As for what concerns medicines, this time can reach decades, demanding the evaluation of barriers through translational research. Our aim was to review the literature in order to identify the steps of translational research, as well as normative acts, public health policies, and the key agents in the Brazilian context. For the identification of translational research framework, a systematic search was carried out on PubMed, Embase, and Lilacs databases, with 23 publications selected. Official websites were consulted to gather informa- tion on policies and actors. As a result, the literature initially pointed to one step ( from bench to bedside), recently incorporating the additional steps of research synthesis and the public health impact assessment. Several actors are transversally involved in translational research, such as universities, research institutions, and funding agencies. It is observed that Brazil has implemented important policies in the fields of pharmaceutical services, research, science, technology, and innovation in health, which may potentially integrate resources, actors, and efforts aimed to the practical application of research results in clinical practice, improving the health and life condi- tion of the population.
Translational research has come up with the purpose of reducing the time gap between basic research and its clinical application. As for what concerns medicines, this time can reach decades, demanding the evaluation of barriers through translational research. Our aim was to review the literature in order to identify the steps of translational research, as well as normative acts, public health policies, and the key agents in the Brazilian context. For the identification of translational research framework, a systematic search was carried out on PubMed, Embase, and Lilacs databases, with 23 publications selected. Official websites were consulted to gather informa- tion on policies and actors. As a result, the literature initially pointed to one step ( from bench to bedside), recently incorporating the additional steps of research synthesis and the public health impact assessment. Several actors are transversally involved in translational research, such as universities, research institutions, and funding agencies. It is observed that Brazil has implemented important policies in the fields of pharmaceutical services, research, science, technology, and innovation in health, which may potentially integrate resources, actors, and efforts aimed to the practical application of research results in clinical practice, improving the health and life condi- tion of the population.
Description
Palavras-chave
Pesquisa médica translacional, Sistemas de saúde, Política de saúde, Assistência farmacêutica, Medicamentos, Translational medical research, Health systems, Health policy, Pharmaceutical services, Pharmaceutical preparations
Citação
Lupatini EO, Barreto JOM, Zimmermann IR, Silva EN. Medicamentos e pesquisa translacional: etapas, atores e políticas de saúde no contexto brasileiro. Saúde Debate. 2019 nov;43 (spe2): 181-99. doi: 10.1590/0103-11042019S214